哮喘与认知之间的关系：库珀中心纵向研究。
Relationship between asthma and cognition: the Cooper Center Longitudinal Study.
机构信息
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390-8849, USA.
出版信息
Allergy. 2013 Apr;68(4):545-8. doi: 10.1111/all.12125. Epub 2013 Feb 15.
BACKGROUND
Minimal data are available on the relationship between asthma and cognitive performance. In this report, we examine the relationship between asthma and cognitive performance in older adults, a subpopulation with elevated risk of cognitive impairment.
METHODS
We conducted a cross-sectional, retrospective analysis of 1380 participants age ≥55 who completed preventive health examinations at the Cooper Clinic in Dallas, TX. Cognition was assessed using the Montreal Cognitive Assessment (MoCA), a brief test for mild cognitive impairment. Data were analyzed in a multiple logistic regression using MoCA scores suggestive of cognitive impairment as the dependent variable.
RESULTS
When controlling for demographic characteristics, self-rated health status, inhaled corticosteroid use, and FEV1 /FVC, asthma were associated with 78% increased risk of cognitive impairment (P = 0.02) as defined by MoCA score.
CONCLUSIONS
In the largest sample examined to date, we have identified a significant relationship between asthma and cognitive impairment in older people.
背景
关于哮喘与认知表现之间的关系，目前仅有少量数据。在本报告中，我们研究了老年人群体（认知障碍风险较高的亚群）中哮喘与认知表现之间的关系。
方法
我们对在德克萨斯州达拉斯市库珀诊所接受预防保健检查的 1380 名年龄≥55 岁的参与者进行了横断面、回顾性分析。使用蒙特利尔认知评估（MoCA）评估认知能力，这是一种用于轻度认知障碍的简短测试。使用 MoCA 评分提示认知障碍的多逻辑回归分析数据作为因变量。
结果
在控制人口统计学特征、自我报告的健康状况、吸入皮质类固醇的使用和 FEV1/FVC 后，哮喘与认知障碍的风险增加 78%（P=0.02）相关，其定义为 MoCA 评分。
结论
在迄今为止检查的最大样本中，我们确定了哮喘与老年人认知障碍之间存在显著关系。
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