Minor Gerard, Ochoa Juan B, Storm Heidi, Periman Seletha
Children's Center for GI and Nutrition, Hollywood, FL, USA.
Nestlé Health Science, Florham Park, NJ, USA.
Glob Pediatr Health. 2016 Dec 21;3:2333794X16681887. doi: 10.1177/2333794X16681887. eCollection 2016.
Children with developmental delays are often dependent on enteral nutrition. The aim of our study was to evaluate improvement in tolerance parameters in these children who were switched from an intact protein formula to a 100% whey, peptide-based formula. A retrospective chart review of children with developmental delays who were failing to reach adequate nutritional goals on standard polymeric formulas were switched to a 100% whey peptide-based formula. Enteral volume goals, caloric goals, and change in medication used to improve feeding tolerance were assessed before and after formula switch. Medical records of 13 children (aged 8.4 ± 4.6 years) met criteria. All children had a primary diagnosis of developmental delay, and 77% were fed via gastrostomy tube. Of the 13 children assessed, 92% experienced improved feeding tolerance, and 75% of these reported the time to improvement within 1 week after formula switch. Feeding tolerance parameters that improved were vomiting (86%), gagging and retching (75%), high residual volumes (63%), constipation (43%), diarrhea (100%), and poor weight gain (100%). Switching to a 100% whey, peptide-based formula improved symptoms of feeding intolerance in the majority of these developmentally delayed children.
发育迟缓的儿童通常依赖肠内营养。我们研究的目的是评估这些从完整蛋白质配方奶粉转换为100%乳清蛋白肽基配方奶粉的儿童在耐受性参数方面的改善情况。对那些在标准聚合物配方奶粉上未能达到足够营养目标的发育迟缓儿童进行了回顾性病历审查，这些儿童被转换为100%乳清蛋白肽基配方奶粉。在配方奶粉转换前后，评估肠内体积目标、热量目标以及用于改善喂养耐受性的药物变化。13名儿童（年龄8.4±4.6岁）的病历符合标准。所有儿童的主要诊断均为发育迟缓，77%通过胃造瘘管喂养。在评估的13名儿童中，92%的儿童喂养耐受性得到改善，其中75%报告在配方奶粉转换后1周内出现改善。改善的喂养耐受性参数包括呕吐（86%）、作呕和干呕（75%）、高残余量（63%）、便秘（43%）、腹泻（100%）和体重增加不佳（100%）。转换为100%乳清蛋白肽基配方奶粉改善了大多数这些发育迟缓儿童的喂养不耐受症状。
