Department of Psychology, Università Cattolica del Sacro Cuore, Milan, Italy.
Azienda Ospedaliera Niguarda Ca' Granda, Milan, Italy.
Eur J Neurol. 2017 Apr;24(4):578-586. doi: 10.1111/ene.13246. Epub 2017 Feb 23.
Studies investigating psychological interventions for the promotion of well-being in people with amyotrophic lateral sclerosis (ALS) are lacking. The purpose of the current study was to examine the use of an ALS-specific mindfulness-based intervention for improving quality of life in this population.
A randomized, open-label and controlled clinical trial was conducted on the efficacy of an ALS-specific meditation programme in promoting quality of life. Adults who received a diagnosis of ALS within 18 months were randomly assigned either to usual care or to an 8-week meditation training based on the original mindfulness-based stress reduction programme and tailored for people with ALS. Quality of life, assessed with the ALS-Specific Quality of Life Revised scale, represented the primary outcome, whilst secondary outcomes included anxiety and depression, assessed with the Hospital Anxiety and Depression Scale, and specific quality of life domains. Participants were assessed at recruitment and after 2, 6 and 12 months. The efficacy of the treatment was assessed on an intention-to-treat basis of a linear mixed model.
A hundred participants were recruited between November 2012 and December 2014. Over time, there was a significant difference between the two groups in terms of quality of life (β = 0.24, P = 0.015, d = 0.89). Significant differences between groups over time were also found for anxiety, depression, negative emotions, and interaction with people and the environment.
An ALS-specific meditation programme is beneficial for the quality of life and psychological well-being of people with ALS.
目前缺乏研究心理干预对肌萎缩侧索硬化症（ALS）患者幸福感促进作用的研究。本研究旨在探讨针对 ALS 的正念干预对改善该人群生活质量的效果。
采用随机、开放标签和对照临床试验，研究针对 ALS 的特定冥想方案对促进生活质量的疗效。在 18 个月内被诊断为 ALS 的成年人，随机分为常规护理组或基于原始正念减压方案并针对 ALS 患者量身定制的 8 周冥想训练组。主要结局为生活质量，采用 ALS 特定生活质量修订量表评估，次要结局包括焦虑和抑郁，采用医院焦虑抑郁量表评估，以及特定生活质量领域。参与者在招募时和 2、6 和 12 个月时进行评估。采用线性混合模型进行意向治疗的治疗效果评估。
2012 年 11 月至 2014 年 12 月期间招募了 100 名参与者。随着时间的推移，两组在生活质量方面存在显著差异（β=0.24，P=0.015，d=0.89）。组间在焦虑、抑郁、负性情绪以及与人和环境的互动方面也存在显著的时间差异。
针对 ALS 的冥想方案有益于 ALS 患者的生活质量和心理健康。
