Department of Organic Chemistry, Indian Institute of Science , Bangalore 560 012, Karnataka, India.
J Org Chem. 2017 Mar 17;82(6):3084-3093. doi: 10.1021/acs.joc.7b00073. Epub 2017 Mar 7.
Synthesis of polyfunctionalized aminothioalkenes has been demonstrated using iodine as a catalyst (30 mol %) and dimethyl sulfoxide as an oxidant under metal-free reaction conditions. This methodology allows a facile sulfenylation of enaminones with a broad range of heterocyclic thiols and thiones using cross dehydrogenative coupling methods. In addition, this strategy is highly practical as it employs inexpensive and readily available iodine and DMSO with a short reaction time. The current methodology is one of the simplest methods and provides a straightforward approach to sulfenylation of enaminones via the cross dehydrogenative coupling method.
多官能化的氨硫烯的合成已经被证明可以使用碘作为催化剂（30mol%）和二甲亚砜作为氧化剂，在无金属反应条件下进行。这种方法允许使用交叉脱氢偶联方法，轻松地将烯胺酮与广泛的杂环硫醇和硫酮进行磺化。此外，该策略非常实用，因为它使用了廉价且易得的碘和 DMSO，并具有较短的反应时间。目前的方法是最简单的方法之一，通过交叉脱氢偶联方法为烯胺酮的磺化提供了一种直接的途径。
