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一名患有严重溃疡性结肠炎的免疫功能低下患者发生侵袭性肺曲霉病。

Invasive pulmonary aspergillosis in an immunocompromised patient with severe ulcerative colitis.

作者信息

Marti Aguado David, Ballester María Pilar, Bosca Watts Marta Maia

机构信息

Aparato Digestivo, Hospital Clínico Universitario Valencia, España.

Aparato Digestivo, Hospital Clínico Universitario Valencia.

出版信息

Rev Esp Enferm Dig. 2017 Apr;109(4):316-317. doi: 10.17235/reed.2017.4564/2016.

DOI:10.17235/reed.2017.4564/2016
PMID:28229616
Abstract

Inflammatory bowel disease patients at risk of opportunistic infections are those treated with immunomodulators. Toruner and colleagues found that corticosteroid use was more commonly associated with fungal infections. We present a case of invasive pulmonary Aspergillosis due to corticosteroid therapy in the context of a severe Ulcerative Colitis flare. We want to highlight the relationship between Aspergillus fumigatus and horses; and the use of leucocitapheresis combined with mesalazine as an effective treatment option in this patients who can not take more immunosuppressive therapy.

摘要

有机会性感染风险的炎症性肠病患者是那些接受免疫调节剂治疗的患者。托鲁纳及其同事发现,使用皮质类固醇更常与真菌感染相关。我们报告一例在严重溃疡性结肠炎发作背景下因皮质类固醇治疗导致的侵袭性肺曲霉病病例。我们想强调烟曲霉与马的关系;以及对于不能接受更多免疫抑制治疗的此类患者,使用白细胞单采术联合美沙拉嗪作为一种有效的治疗选择。

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Invasive pulmonary aspergillosis in an immunocompromised patient with severe ulcerative colitis.一名患有严重溃疡性结肠炎的免疫功能低下患者发生侵袭性肺曲霉病。
Rev Esp Enferm Dig. 2017 Apr;109(4):316-317. doi: 10.17235/reed.2017.4564/2016.
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High-dose mesalazine treatment for ulcerative colitis patients who relapse under low-dose maintenance therapy.高剂量美沙拉嗪治疗在低剂量维持治疗下复发的溃疡性结肠炎患者。
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Exploration of fecal microbiota in newly diagnosed patients with inflammatory bowel disease using shotgun metagenomics.使用鸟枪法宏基因组学对新诊断的炎症性肠病患者的粪便微生物群进行探索。
Front Cell Infect Microbiol. 2025 Jul 1;15:1595884. doi: 10.3389/fcimb.2025.1595884. eCollection 2025.
2
Alterations in the mucosa-associated fungal microbiota in patients with ulcerative colitis.溃疡性结肠炎患者黏膜相关真菌微生物群的改变。
Oncotarget. 2017 Nov 20;8(64):107577-107588. doi: 10.18632/oncotarget.22534. eCollection 2017 Dec 8.