Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, China.
Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu, China.
Helicobacter. 2017 Oct;22(5). doi: 10.1111/hel.12398. Epub 2017 Jun 9.
The results from observational studies on the relationship between helicobacter pylori (H. pylori) infection and Parkinson's disease remain controversial. A meta-analysis was conducted to evaluate the association between helicobacter pylori infection and Parkinson's disease.
A comprehensive literature search was performed on relevant studies published from January 1983 to January 2017 in PubMed, Web of Science and EMBASE databases. The fixed or random effects model was used to pool the odds ratio with 95% confidence interval from individual studies. Publication bias was estimated by Egger's test and the funnel plot.
Eight eligible studies involving 33 125 participants were included in this meta-analysis. Compared with the no helicobacter pylori infected person, the pooled odds ratio of Parkinson's disease in helicobacter pylori infected person was 1.59 (95% confidence interval: 1.37-1.85). In subgroup analyzes, the combined odds ratios were 1.96 (1.23-3.12) in Asia, 1.55 (1.32-1.82) in Europe, 1.59 (1.35-1.88) in case-control studies, 1.56 (1.01-2.39) in cross-sectional studies, 1.56 (1.32-1.85) in studies with confounders adjusted, and 1.71 (1.21-2.43) in studies with no confounder adjusted, respectively.
This meta-analysis indicated that H. pylori infection might be associated with the risk of Parkinson's disease.
关于幽门螺杆菌（H. pylori）感染与帕金森病之间关系的观察性研究结果仍存在争议。进行了一项荟萃分析，以评估幽门螺杆菌感染与帕金森病之间的关联。
在 PubMed、Web of Science 和 EMBASE 数据库中，对 1983 年 1 月至 2017 年 1 月期间发表的相关研究进行了全面的文献检索。使用固定或随机效应模型汇总来自个体研究的优势比及其 95%置信区间。使用 Egger 检验和漏斗图评估发表偏倚。
纳入了八项符合条件的研究，共涉及 33125 名参与者。与未感染幽门螺杆菌的人相比，感染幽门螺杆菌的人患帕金森病的合并优势比为 1.59（95%置信区间：1.37-1.85）。在亚组分析中，亚洲人群的合并优势比为 1.96（1.23-3.12），欧洲人群为 1.55（1.32-1.82），病例对照研究为 1.59（1.35-1.88），横断面研究为 1.56（1.01-2.39），调整混杂因素的研究为 1.56（1.32-1.85），未调整混杂因素的研究为 1.71（1.21-2.43）。
这项荟萃分析表明，幽门螺杆菌感染可能与帕金森病的风险相关。
