Pan Debiao, Wang Shi, Ye Hailin, Xu Shengqian, Ye Guanxiong
Department of General Surgery, Lishui People's Hospital, Lishui, Zhejiang, P.R. China.
J Cancer Res Ther. 2016 Dec;12(Supplement):C291-C294. doi: 10.4103/0973-1482.200761.
The aim of this study was to assess Ezrin expression in the primary hepatic carcinoma patients and associated with clinical, pathological characteristics.
Fifty-one patients with primary hepatocellular carcinoma (PHC) with completed clinical data were retrospectively analyzed in this study. The Ezrin expression in PHC and normal control liver tissue was tested by immunohistochemical assay. The Ezrin expression and relationship with clinical characteristics were evaluated.
The Ezrin positive rate were 66.7% and 15.7% with expression score of 3.21 ± 1.46 and 0.60 ± 1.10, respectively, in the cancer tissue and control tissue with statistical difference (P < 0.05). The Ezrin expression was associated with the metastasis status of the patients (P < 0.05) but not associated with the age (P > 0.05), gender (P > 0.05), differentiation (P > 0.05), and tumor diameter (P > 0.05).
Ezrin protein is highly expressed in human PHC tissue which can be used for the prediction of metastasis disease.
本研究旨在评估埃兹蛋白（Ezrin）在原发性肝癌患者中的表达情况，并探讨其与临床、病理特征的相关性。
本研究回顾性分析了51例临床资料完整的原发性肝细胞癌（PHC）患者。采用免疫组织化学法检测PHC组织及正常对照肝组织中Ezrin的表达情况。评估Ezrin表达及其与临床特征的关系。
癌组织和对照组织中Ezrin阳性率分别为66.7%和15.7%，表达评分分别为3.21±1.46和0.60±1.10，差异有统计学意义（P<0.05）。Ezrin表达与患者的转移状态相关（P<0.05），但与年龄（P>0.05）、性别（P>0.05）、分化程度（P>0.05）及肿瘤直径（P>0.05）无关。
Ezrin蛋白在人PHC组织中高表达，可用于预测转移性疾病。
