Lévy D, Kettmann R, Marchand P, Djilali S, Parodi A L
Laboratoire Anatomie Pathologique et Immunogénétique INRA, Ecole Nationale Vétérinaire, Maisons-Alfort, France.
Leukemia. 1987 May;1(5):463-5.
Bovine leukemia virus (BLV) is experimentally infectious for sheep. Virus production does not occur in the animals, but only after in vitro cultivation of infected lymphocytes in the presence of phytohemagglutinin. Lipopolysaccharide or dextran sulfate 500 had no effect. After panning separation, it was possible to demonstrate that, in peripheral blood lymphocytes, BLV was integrated in the B lymphocytes only and that BLV expression took place in a fraction of this population. The ovine leukemia may constitute a good experimental model for understanding the virus-induced leukemias of the BLV-human T cell leukemia virus group.
牛白血病病毒（BLV）可通过实验感染绵羊。病毒不会在动物体内产生，而是仅在植物血凝素存在的情况下对感染的淋巴细胞进行体外培养后才会产生。脂多糖或硫酸葡聚糖500没有作用。淘选分离后，可以证明，在外周血淋巴细胞中，BLV仅整合在B淋巴细胞中，且BLV表达发生在该群体的一部分细胞中。绵羊白血病可能构成一个很好的实验模型，用于理解BLV-人类T细胞白血病病毒组的病毒诱导白血病。
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