Agil Rania, Patterson Zachary R, Mackay Harry, Abizaid Alfonso, Hosseinian Farah
Food Science & Nutrition Program, Department of Chemistry, Carleton University, Ottawa, ON K1S 5B6, Canada.
Department of Neuroscience, Carleton University, Ottawa, ON K1S 5B6, Canada.
Foods. 2016 Jan 5;5(1):5. doi: 10.3390/foods5010005.
Triticale (× Whitm.) is a cereal grain with high levels of alkyresorcinols (AR) concentrated in the bran. These phenolic lipids have been shown to reduce or inhibit triglyceride accumulation and protect against oxidation; however, their biological effects have yet to be evaluated . The purpose of this study was to determine the effects of ARs extracted from triticale bran (TB) added to a high-fat diet on the development of obesity and oxidative stress. CF-1 mice were fed a standard low-fat (LF) diet, a 60% high-fat diet (HF) and HF diets containing either 0.5% AR extract (HF-AR), 10% TB (HF-TB), or 0.5% vitamin E (HF-VE). Energy intake, weight gain, glucose tolerance, fasting blood glucose (FBG) levels, and body composition were determined. Oxygen radical absorbance capacity (ORAC), superoxide dismutase (SOD) activity, and glutathione (GSH) assays were performed on mice liver and heart tissues. The findings suggest that ARs may serve as a preventative measure against risks of oxidative damage associated with high-fat diets and obesity through their application as functional foods and neutraceuticals. Future studies aim to identify the mechanisms of action of ARs and the individual homologs involved in their favorable biological effects.
小黑麦（× 惠特姆）是一种谷物，其富含烷基间苯二酚（AR）的麸皮中含量较高。这些酚类脂质已被证明可减少或抑制甘油三酯的积累并防止氧化；然而，它们的生物学效应尚未得到评估。本研究的目的是确定添加到高脂饮食中的小黑麦麸皮（TB）中提取的AR对肥胖和氧化应激发展的影响。给CF-1小鼠喂食标准低脂（LF）饮食、60%高脂饮食（HF）以及含有0.5%AR提取物（HF-AR）、10%TB（HF-TB）或0.5%维生素E（HF-VE）的HF饮食。测定能量摄入、体重增加、葡萄糖耐量、空腹血糖（FBG）水平和身体组成。对小鼠肝脏和心脏组织进行氧自由基吸收能力（ORAC）、超氧化物歧化酶（SOD）活性和谷胱甘肽（GSH）测定。研究结果表明，AR作为功能性食品和营养保健品，可作为预防与高脂饮食和肥胖相关的氧化损伤风险的措施。未来的研究旨在确定AR的作用机制以及参与其有益生物学效应的各个同系物。
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