Lesser R W, Spector G J, Devineni V R
Department of Otolaryngology, Hahnemann University Hospital, Philadelphia, Pennsylvania.
Otolaryngol Head Neck Surg. 1987 Jan;96(1):43-7. doi: 10.1177/019459988709600108.
Twenty-four patients with malignant tumors of the external auditory canal and middle ear, originally seen between 1960 and 1980, were reviewed retrospectively. Seventeen patients had epidermoid carcinoma, one had adenocarcinoma, three had rhabdomyosarcoma, and one had osteosarcoma. At presentation, four had disease confined to the external auditory canal, three had superficial invasion of the bony canal, four had deeply invasive disease, and thirteen had disease that extended beyond the temporal bone. Treatment consisted of radiation, surgery, and combination therapy. Four patients with osteosarcoma or rhabdomyosarcoma received adjuvant chemotherapy. Five years after therapy, one of four patients with external auditory canal tumor died of disease, and two died of intercurrent disorders. One of three patients with superficial temporal bone invasion and two of four patients with deeply invasive tumor died of their disease; another died of intercurrent disorder. Twelve of 13 patients with tumor beyond the temporal bone died.
对1960年至1980年间初诊的24例外耳道和中耳恶性肿瘤患者进行了回顾性研究。17例为表皮样癌，1例为腺癌，3例为横纹肌肉瘤，1例为骨肉瘤。初诊时，4例病变局限于外耳道，3例为骨管浅层侵犯，4例为深层浸润性病变，13例病变超出颞骨。治疗方法包括放疗、手术及联合治疗。4例骨肉瘤或横纹肌肉瘤患者接受了辅助化疗。治疗后5年，4例外耳道肿瘤患者中有1例死于疾病，2例死于并发疾病。3例颞骨浅层侵犯患者中有1例、4例深层浸润性肿瘤患者中有2例死于疾病；另1例死于并发疾病。13例肿瘤超出颞骨的患者中有12例死亡。
