解开胰腺癌转移中的遗传学和表观遗传学之谜。
Untangling the genetics from the epigenetics in pancreatic cancer metastasis.
机构信息
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
出版信息
Nat Genet. 2017 Feb 24;49(3):323-324. doi: 10.1038/ng.3798.
DOI:10.1038/ng.3798
PMID:28232730
Abstract
Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.
摘要
对胰腺癌患者体内的原发肿瘤和转移灶进行的比较基因组分析，揭示了癌症细胞向远处扩散的复杂克隆动态。最近的研究表明，非遗传机制在这一过程中起作用，特别是染色质状态和代谢的波动，这可以使原发肿瘤中的少数稀有细胞获得转移潜能。
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