1] Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD, USA [2] Division of Refractory Cancer Research, National Cancer Center Research Institute, Tokyo, Japan.
Oncogene. 2013 Nov 7;32(45):5253-60. doi: 10.1038/onc.2013.29. Epub 2013 Feb 18.
Efficient metastasis is believed as the result of multiple genetic, epigenetic and/or post-translational events in the lifetime of a carcinoma. At the genetic level, these events may be categorized into those that occur during carcinogenesis, and those that occur during subclonal evolution. This review summarizes current knowledge of the genetics of pancreatic cancer from its initiation within a normal cell until the time that is has disseminated to distant organs, many features of which can be extrapolated to other solid tumor types. The implications of these findings to personalize genome analyses of an individual patient's tumor are also discussed.
人们认为，有效的转移是癌在其一生中发生的多种遗传、表观遗传和/或翻译后事件的结果。在遗传水平上，这些事件可分为在癌变过程中发生的事件和在亚克隆进化过程中发生的事件。本综述总结了目前对胰腺癌遗传学的认识，从正常细胞内的起始到已经扩散到远处器官的过程，其中许多特征可以外推到其他实体肿瘤类型。还讨论了这些发现对个体患者肿瘤的个体化基因组分析的意义。
