Farecki Marie-Louise, Gutfleisch Matthias, Faatz Henrik, Rothaus Kai, Heimes Britta, Spital Georg, Lommatzsch Albrecht, Pauleikhoff Daniel
Department of Opthalmology, St. Franziskus Hospital, Hohenzollernring 74, 48145, Münster, Germany.
Graefes Arch Clin Exp Ophthalmol. 2017 May;255(5):913-921. doi: 10.1007/s00417-017-3588-y. Epub 2017 Feb 23.
BACKGROUND: With FA and SD-OCT, different types of CNV in exudative AMD may be differentiated: type 1 CNV (within the sub-RPE space, typically corresponding to angiographically occult CNV), type 2 CNV (within the subretinal space, typically corresponding to angiographically classic CNV) and type 3 NV (intraretinal retinal angiomatous proliferation). OCT-angiography (OCT-A) is a new method to visualize vasculature based on flow characteristics. A correlation of type 1 and 2 CNV was performed. METHODS: Thirty-six eyes (17 type 1 CNV, 9 combined type 1 and 2 CNV, and 10 type 2 CNV) of 36 patients were examined by FA, SD-OCT and OCT-A. Standardized OCT-A segmentations were performed at the level of mid-choroid, choriocapillaris (CC), RPE and outer retina. On these images the size and demarcation of CNV lesions were classified: "not distinguishable", "minor" or "sharp" demarcation. Furthermore, the size of the different CNV subtypes was determined and compared. RESULTS: Both types of CNV were visible in OCT-A. They could be detected on the slabs "mid-choroid", "CC" and "RPE". While type 1 CNV showed most often a minor demarcation from the surrounding vasculature, type 2 CNV showed nearly always a sharp demarcation. In addition, type 2 CNV extended into the slab "outer retina" and were much smaller than type 1 CNV. CONCLUSIONS: Different types of CNV in exudative AMD can be visualized and differentiated with OCT-A. Type 1 CNV were larger with minor demarcation from the surrounding vasculature and were visible on the slab "mid-choroid", "CC" and "RPE". In contrast, type 2 CNV demonstrated a sharp demarcation from the surrounding vasculature reaching the slab "outer retina".
Graefes Arch Clin Exp Ophthalmol. 2017-5
Klin Monbl Augenheilkd. 2017-9
Graefes Arch Clin Exp Ophthalmol. 2020-4
IEEE Int Conf Comput Vis Workshops. 2023-10
Middle East Afr J Ophthalmol. 2023
Med Hypothesis Discov Innov Ophthalmol. 2021-8-5
Dev Ophthalmol. 2016
Klin Monbl Augenheilkd. 2015-9