Institute of Legal Medicine, University of Bonn, Bonn, Germany.
Int J Legal Med. 2017 Nov;131(6):1707-1718. doi: 10.1007/s00414-017-1566-x. Epub 2017 Feb 23.
The expression of heat shock proteins (hsps) increases in cases of hyperthermal cellular stress in order to protect cellular structures. Hsps can be visualized with immunohistochemical staining. We examined 48 cases of death from fire and excessive heat and a control group of 100 deaths without any perimortem thermal stress, measuring both the hsp27 and hsp70 expressions in myocardial, pulmonary, and renal tissues. The results revealed a correlation between hsp expression and survival time. Hsps are expressed rapidly within seconds or minutes after exposure to heat stress. In particular, hsp27 is expressed fast in high levels, whereas hsp70 expression is higher in the pulmonary and renal tissue of long-term survivors. In the myocardial tissue, hsp27 expression dominated in both short- and long-term survival. The expression pattern is strongly dependent on the organ structure and the survival time, which should be considered in future postmortem studies on hsps.
热休克蛋白（hsps）的表达在过热的细胞应激情况下增加，以保护细胞结构。可以通过免疫组织化学染色来观察 hsps。我们检查了 48 例死于火灾和过热的病例和 100 例无生前热应激的对照组，测量了心肌、肺和肾组织中的 hsp27 和 hsp70 表达。结果表明 hsp 表达与存活时间之间存在相关性。hsps 在暴露于热应激后的几秒钟或几分钟内迅速表达。特别是 hsp27 以高水平快速表达，而 hsp70 在长期幸存者的肺和肾组织中的表达更高。在心肌组织中，hsp27 表达在短期和长期存活中均占主导地位。表达模式强烈依赖于器官结构和存活时间，这在未来的 hsps 死后研究中应该加以考虑。
