Shan Ling, Bao Ai-Min, Swaab Dick F
Department of Neurobiology, Key Laboratory of Medical Neurobiology of Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China.
Netherlands Institute for Neuroscience, Institute of the Royal Netherlands Academy of Arts and Sciences, University of Amsterdam, Meibergdreef 47, Amsterdam, 1105 BA, The Netherlands.
Handb Exp Pharmacol. 2017;241:259-276. doi: 10.1007/164_2016_125.
Compared to other monoamine neurotransmitters, information on the association between the histaminergic system and neuropsychiatric disorders is scarce, resulting in a lack of histamine-related treatment for these disorders. The current chapter tries to combine information obtained from genetic studies, neuroimaging, post-mortem human brain studies and cerebrospinal fluid measurements with data from recent clinical trials on histamine receptor agonists and antagonists, with a view to determining the possible role of the histaminergic system in neuropsychiatric disorders and to pave the way for novel histamine-related therapeutic strategies.
与其他单胺类神经递质相比，关于组胺能系统与神经精神疾病之间关联的信息较少，导致缺乏针对这些疾病的组胺相关治疗方法。本章试图将基因研究、神经影像学、人类尸检脑研究和脑脊液测量所获得的信息，与近期关于组胺受体激动剂和拮抗剂的临床试验数据相结合，以期确定组胺能系统在神经精神疾病中可能发挥的作用，并为新型组胺相关治疗策略铺平道路。
