乙醇对大鼠脑内组胺代谢及释放的影响。II. 组胺能通路的区域

Influence of ethanol on histamine metabolism and release in the rat brain. II. Regions of the histaminergic pathway.

作者信息

Subramanian N, Schinzel W, Mitznegg P, Estler C J

出版信息

Pharmacology. 1980;20(1):42-5. doi: 10.1159/000137343.

Abstract

Following acute alcohol administration (80-160 mg/100 g body weight) histamine levels of rat brain cortex and thalamus were elevated and histidine decarboxylase activity was decreased. The effect was less pronounced after chronic alcohol treatment (15% v/v in drinking water for 4 weeks). In the striatum there was no change in the metabolic pattern of histamine. Histamine-N-methyltransferase was unaffected in either case. Depolarisation-induced release of histamine was inhibited by alcohol in the hypothalamus, thalamus and cortex. The results indicate that ethanol affects the histamine metabolism and release processes in the histaminergic pathway of the brain.

摘要

急性给予酒精（80 - 160毫克/100克体重）后，大鼠大脑皮层和丘脑的组胺水平升高，组氨酸脱羧酶活性降低。慢性酒精处理（饮用水中15% v/v，持续4周）后，这种作用不太明显。纹状体中组胺的代谢模式没有变化。组胺 - N - 甲基转移酶在两种情况下均未受影响。在下丘脑、丘脑和皮层中，酒精抑制了去极化诱导的组胺释放。结果表明，乙醇会影响大脑组胺能通路中的组胺代谢和释放过程。