源自花生四烯酸和二十碳五烯酸的脂氧素及相关化合物的命名

Nomenclature of lipoxins and related compounds derived from arachidonic acid and eicosapentaenoic acid.

作者信息

Serhan C N, Wong P Y, Samuelsson B

机构信息

Hematology Division, Brigham and Women's Hospital, Boston, MA 02115.

出版信息

Prostaglandins. 1987 Aug;34(2):201-4. doi: 10.1016/0090-6980(87)90243-7.

DOI:10.1016/0090-6980(87)90243-7

PMID:2823318

Abstract

Oxygenated derivates of arachidonic acid and eicosapentaenoic acid which contain conjugated tetraene structures and are non-cyclized C20 carboxylic acids were first isolated and characterized from human and porcine leukocytes (Serhan, C.N. et al, 1984, Biochem. Biophys. Res. Commun. 118, 943-949; Wong, P.Y.-K., et al, 1985, Biochem. Biophys. Res. Commun. 126, 765-775). The trivial names lipoxins and lipoxenes have been introduced for compounds belonging to each of these series. Here, we propose that tetraene-containing compounds derived from arachidonic acid be denoted as lipoxins (LX) of the four series (i.e. lipoxin A4 or LXA4 and lipoxin B4 or LXB4) and those derived from eicosapentaenoic be termed lipoxins of the five series (i.e. lipoxin A5 or LXA5 and lipoxin B5 or LXB5).

摘要

含有共轭四烯结构且为非环化C20羧酸的花生四烯酸和二十碳五烯酸的氧化衍生物最初是从人和猪的白细胞中分离并鉴定出来的（塞尔汉，C.N.等人，1984年，《生物化学与生物物理学研究通讯》118卷，943 - 949页；黄，P.Y.-K.等人，1985年，《生物化学与生物物理学研究通讯》126卷，765 - 775页）。已为属于这两个系列的每一类化合物引入了俗名脂氧素和脂氧烯。在此，我们提议将源自花生四烯酸的含四烯化合物表示为四个系列的脂氧素（LX）（即脂氧素A4或LXA4以及脂氧素B4或LXB4），而将源自二十碳五烯酸的那些化合物称为五个系列的脂氧素（即脂氧素A5或LXA5以及脂氧素B5或LXB5）。