儿童急性髓系白血病合并中枢神经系统受累的临床表现及影像学表现
Presenting features and imaging in childhood acute myeloid leukemia with central nervous system involvement.
作者信息
Ranta Susanna, Palomäki Maarit, Levinsen Mette, Taskinen Mervi, Abrahamsson Jonas, Hasle Henrik, Jahnukainen Kirsi, Heyman Mats, Harila-Saari Arja
机构信息
Department of Women's and Children's Health, Childhood Cancer Research Unit, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden.
Department of Radiology, Helsinki University Central Hospital, Helsinki, Finland.
出版信息
Pediatr Blood Cancer. 2017 Dec;64(12). doi: 10.1002/pbc.26459. Epub 2017 Feb 24.
Central nervous system (CNS) involvement in childhood acute myeloid leukemia (AML) can manifest as leukemic cells in the cerebrospinal fluid, a solid CNS tumor, or as neurological symptoms. We evaluated the presenting symptoms and neuroimaging findings in 33 of 34 children with AML and CNS involvement at diagnosis in the period 2000-2012 in Sweden, Finland, and Denmark. Imaging was performed in 22 patients, of whom 16 had CNS-related symptoms. Seven patients, including all but two with facial palsy, had mastoid cell opacification, considered an incidental finding. The frequent involvement of the mastoid bone with facial palsy warrants evaluation in larger series.
中枢神经系统（CNS）受累于儿童急性髓系白血病（AML）时，可表现为脑脊液中的白血病细胞、中枢神经系统实体瘤或神经系统症状。我们评估了2000年至2012年期间在瑞典、芬兰和丹麦诊断时患有AML且中枢神经系统受累的34例儿童中的33例的首发症状和神经影像学表现。22例患者进行了影像学检查，其中16例有中枢神经系统相关症状。7例患者出现乳突细胞混浊，包括除2例面瘫患者外的所有患者，这被视为偶然发现。乳突骨频繁受累伴面瘫值得在更大系列中进行评估。
Zotero 插件