双侧周围性面神经麻痹和乳突浸润作为复发性急性髓细胞白血病的症状。

Bilateral peripheral facial palsy and mastoid infiltration as symptoms of relapsed acute myeloid leukemia.

作者信息

Leite da Silveira P, Gonçalves Silva V, Rizzato Paschoal J, Nizam Pfeilsticker L

机构信息

Department of Otolaryngology and Head and Neck Surgery, Universidade Estadual de Campinas (Unicamp, State University at Campinas), School of Medical Sciences, PO Box 6111, CEP 13083-970, Campinas, SP, Brazil.

出版信息

Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):41-3. doi: 10.1016/j.anorl.2013.09.003. Epub 2014 Apr 1.

DOI:10.1016/j.anorl.2013.09.003

PMID:24703003

Abstract

BACKGROUND

Although Bell's palsy (BP) is the most common cause of peripheral facial palsy (PFP), other etiologies merit investigation.

CASE REPORT

A 60-year-old female patient presented with recurrent bilateral PFP. Although the patient had a history of acute myeloid leukemia (AML), she had initially been diagnosed with BP-related PFP and had been treated accordingly. When the PFP recurred, additional diagnostic tests were performed. The resulting immunohistochemical profile included CD3 positivity in a few reactive T lymphocytes; positivity for myeloperoxidase in atypical cells; and focal positivity for CD34 and proto-oncogene c-kit proteins in neoplastic cells, thus confirming the suspicion of mastoid infiltration caused by relapsed AML.

CONCLUSION

In patients with neoplastic disease, a finding of PFP calls for extensive investigation in order to rule out the involvement of the temporal bone.

摘要

背景

尽管贝尔麻痹（BP）是周围性面神经麻痹（PFP）最常见的病因，但其他病因也值得研究。

病例报告

一名60岁女性患者出现复发性双侧PFP。尽管该患者有急性髓系白血病（AML）病史，但最初被诊断为与BP相关的PFP并接受了相应治疗。当PFP复发时，进行了额外的诊断测试。免疫组化结果显示，少数反应性T淋巴细胞中CD3呈阳性；非典型细胞中髓过氧化物酶呈阳性；肿瘤细胞中CD34和原癌基因c-kit蛋白呈局灶性阳性，从而证实了复发AML导致乳突浸润的怀疑。