Leite da Silveira P, Gonçalves Silva V, Rizzato Paschoal J, Nizam Pfeilsticker L
Department of Otolaryngology and Head and Neck Surgery, Universidade Estadual de Campinas (Unicamp, State University at Campinas), School of Medical Sciences, PO Box 6111, CEP 13083-970, Campinas, SP, Brazil.
Department of Otolaryngology and Head and Neck Surgery, Universidade Estadual de Campinas (Unicamp, State University at Campinas), School of Medical Sciences, PO Box 6111, CEP 13083-970, Campinas, SP, Brazil.
Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):41-3. doi: 10.1016/j.anorl.2013.09.003. Epub 2014 Apr 1.
Although Bell's palsy (BP) is the most common cause of peripheral facial palsy (PFP), other etiologies merit investigation.
A 60-year-old female patient presented with recurrent bilateral PFP. Although the patient had a history of acute myeloid leukemia (AML), she had initially been diagnosed with BP-related PFP and had been treated accordingly. When the PFP recurred, additional diagnostic tests were performed. The resulting immunohistochemical profile included CD3 positivity in a few reactive T lymphocytes; positivity for myeloperoxidase in atypical cells; and focal positivity for CD34 and proto-oncogene c-kit proteins in neoplastic cells, thus confirming the suspicion of mastoid infiltration caused by relapsed AML.
In patients with neoplastic disease, a finding of PFP calls for extensive investigation in order to rule out the involvement of the temporal bone.
尽管贝尔麻痹（BP）是周围性面神经麻痹（PFP）最常见的病因，但其他病因也值得研究。
一名60岁女性患者出现复发性双侧PFP。尽管该患者有急性髓系白血病（AML）病史，但最初被诊断为与BP相关的PFP并接受了相应治疗。当PFP复发时，进行了额外的诊断测试。免疫组化结果显示，少数反应性T淋巴细胞中CD3呈阳性；非典型细胞中髓过氧化物酶呈阳性；肿瘤细胞中CD34和原癌基因c-kit蛋白呈局灶性阳性，从而证实了复发AML导致乳突浸润的怀疑。
对于患有肿瘤性疾病的患者，发现PFP需要进行广泛的检查，以排除颞骨受累的情况。
