用于递送溶瘤病毒治疗神经胶质瘤的间充质基质细胞

Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas.

作者信息

Parker Kerrigan Brittany C, Shimizu Yuzaburo, Andreeff Michael, Lang Frederick F

机构信息

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Bioengineering, Rice University, Houston, Texas, USA.

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; The Brain Tumor Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA; Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan.

出版信息

Cytotherapy. 2017 Apr;19(4):445-457. doi: 10.1016/j.jcyt.2017.02.002. Epub 2017 Feb 21.

DOI:10.1016/j.jcyt.2017.02.002

PMID:28233640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5410175/

Abstract

Mesenchymal stromal cells (MSCs) are a type of adult stem cell that has been exploited for the treatment of a variety of diseases, including cancer. In particular, MSCs have been studied extensively for their ability to treat glioblastoma (GBM), the most common and deadly form of brain cancer in adults. MSCs are attractive therapeutics because they can be obtained relatively easily from patients, are capable of being expanded numerically in vitro, can be easily engineered and are inherently capable of homing to tumors, making them ideal vehicles for delivering biological antitumoral agents. Oncolytic viruses are promising biological therapeutic agents that have been used in the treatment of GBMs, and MSCs are currently being explored as a means of delivering these viruses. Here we review the role of MSCs in the treatment of GBMs, focusing on the intersection of MSCs and oncolytic viruses.

摘要

间充质基质细胞（MSCs）是一种成体干细胞，已被用于治疗包括癌症在内的多种疾病。特别是，MSCs因其治疗胶质母细胞瘤（GBM）的能力而受到广泛研究，GBM是成人中最常见且致命的脑癌形式。MSCs是有吸引力的治疗手段，因为它们可以相对容易地从患者体内获取，能够在体外进行数量扩增，易于改造，并且天生具有归巢到肿瘤的能力，使其成为递送生物抗肿瘤剂的理想载体。溶瘤病毒是有前景的生物治疗剂，已被用于治疗GBM，目前正在探索将MSCs作为递送这些病毒的一种手段。在此，我们综述MSCs在治疗GBM中的作用，重点关注MSCs与溶瘤病毒的交叉点。