State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University , 2699 Qianjin Street, Changchun 130012, P. R. China.
ACS Appl Mater Interfaces. 2017 Apr 5;9(13):11451-11460. doi: 10.1021/acsami.7b00647. Epub 2017 Mar 27.
Efficient targeting is a major challenge in practical photodynamic therapy (PDT). Though the "enhanced permeability and retention" (EPR) effect is a widely used tumor targeting method, magnetic targeting strategy is more promising considering the issue of high targeting efficiency and reducing concentration-dependent toxicity. Herein, magnetic targeting and highly effective FeO@Ce6/C6@silane NPs are reported as a class of precisely controlled photosensitizers (PS) for PDT. On the basis of the amphiphilic silane encapsulation, PS chlorin e6 (Ce6) and Coumarin 6 (C6) as well as FeO NPs were coloaded into the inside hydrophobic environment of amphiphilic silane, forming a theranostic agent for dual-mode imaging guided and magnetic targeting enhanced in vivo PDT agent. To solve the problem of over-irradiation, the coloaded design of C6 and Ce6 molecules can afford the real time PDT monitoring by ratio emissions with same excitation wavelength. When FeO@Ce6/C6@silane and Ce6/C6@silane NPs are compared in in vitro and in vivo experiments, the introduction of FeO in the composite does not affect the PDT efficiency, whereas, in contrast, it brings MRI imaging and magnetic targeting functions. FeO@Ce6/C6@silane injection followed with magnetic field (MF) and light irradiation is important in generating an effective PDT process, showing great potential in tumor therapy.
高效靶向是实际光动力疗法（PDT）的主要挑战。尽管“增强的通透性和保留”（EPR）效应是一种广泛使用的肿瘤靶向方法，但考虑到高靶向效率和降低浓度依赖性毒性的问题，磁性靶向策略更具前景。本文报道了磁性靶向和高效 FeO@Ce6/C6@硅烷 NPs 作为一类精确控制的光敏剂（PS）用于 PDT。基于两亲性硅烷的包裹，PS 叶绿素 e6（Ce6）和香豆素 6（C6）以及 FeO NPs 被共装入两亲性硅烷的内部疏水环境中，形成用于双模式成像引导和磁性靶向增强体内 PDT 剂的治疗剂。为了解决过度照射的问题，C6 和 Ce6 分子的共载设计可以通过具有相同激发波长的比率发射来提供实时 PDT 监测。在体外和体内实验中比较了 FeO@Ce6/C6@硅烷和 Ce6/C6@硅烷 NPs，复合材料中引入 FeO 不会影响 PDT 效率，而相反，它带来了 MRI 成像和磁性靶向功能。FeO@Ce6/C6@硅烷注射后进行磁场（MF）和光照是产生有效 PDT 过程的重要因素，在肿瘤治疗中具有很大的潜力。
