School of Chemistry and Physics, College of Agriculture Engineering and Science, University of KwaZulu-Natal, Durban 4041, South Africa.
Water Research Institute, Council for Scientific and Industrial Research, Accra 8164, Ghana.
Int J Mol Sci. 2022 Mar 16;23(6):3209. doi: 10.3390/ijms23063209.
Antimicrobial photodynamic therapy and allied photodynamic antimicrobial chemotherapy have shown remarkable activity against bacterial pathogens in both planktonic and biofilm forms. There has been little or no resistance development against antimicrobial photodynamic therapy. Furthermore, recent developments in therapies that involve antimicrobial photodynamic therapy in combination with photothermal hyperthermia therapy, magnetic hyperthermia therapy, antibiotic chemotherapy and cold atmospheric pressure plasma therapy have shown additive and synergistic enhancement of its efficacy. This paper reviews applications of antimicrobial photodynamic therapy and non-invasive combination therapies often used with it, including sonodynamic therapy and nanozyme enhanced photodynamic therapy. The antimicrobial and antibiofilm mechanisms are discussed. This review proposes that these technologies have a great potential to overcome the bacterial resistance associated with bacterial biofilm formation.
光动力抗菌疗法和相关的光动力抗菌化学疗法已显示出对浮游和生物膜形式的细菌病原体的显著活性。针对光动力抗菌疗法的耐药性发展很少或没有。此外，最近在涉及光动力抗菌疗法与光热高温疗法、磁热疗法、抗生素化学疗法和冷大气压等离子体疗法相结合的疗法方面的发展表明，其疗效得到了相加和协同增强。本文综述了光动力抗菌疗法的应用及其常与光动力抗菌疗法联合使用的非侵入性联合疗法，包括声动力疗法和纳米酶增强光动力疗法。讨论了抗菌和抗生物膜的机制。本文综述认为，这些技术具有克服与细菌生物膜形成相关的细菌耐药性的巨大潜力。
