Zhou Yixuan, Cao Ziqi, Jiang Lixian, Chen Ying, Cui Xiaoyu, Wu Jianrong, Xie Xue, Wang Longchen, Ying Tao
Jinzhou Medical University Graduate Training Base (Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine), Jinzhou, China.
Department of Ultrasound in Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai, China.
Front Bioeng Biotechnol. 2024 Mar 26;12:1374423. doi: 10.3389/fbioe.2024.1374423. eCollection 2024.
Ovarian cancer presents a substantial challenge due to its high mortality and recurrence rates among gynecological tumors. Existing clinical chemotherapy treatments are notably limited by drug resistance and systemic toxic side effects caused by off target drugs. Sonodynamic therapy (SDT) has emerged as a promising approach in cancer treatment, motivating researchers to explore synergistic combinations with other therapies for enhanced efficacy. In this study, we developed magnetic sonodynamic nanorobot (FeO@SiO-Ce6, FSC) by applying a SiO coating onto FeO nanoparticle, followed by coupling with the sonosensitizer Ce6. The magnetic FSC nanorobot collectives could gather at fixed point and actively move to target site regulated by magnetic field. experiments revealed that the magnetic FSC nanorobot collectives enabled directional navigation to the tumor cell area under guidance. Furthermore, under low-intensity ultrasonic stimulation, FSC nanorobot collectives mediated sonodynamic therapy exhibited remarkable anti-tumor performance. These findings suggest that magnetically actuated sonodynamic nanorobot collectives hold promising potential for application in target cancer therapy.
由于卵巢癌在妇科肿瘤中具有较高的死亡率和复发率，因此它是一个重大挑战。现有的临床化疗治疗明显受到耐药性和非靶向药物引起的全身毒性副作用的限制。声动力疗法（SDT）已成为一种有前景的癌症治疗方法，促使研究人员探索与其他疗法的协同组合以提高疗效。在本研究中，我们通过在FeO纳米颗粒上应用SiO涂层，然后与声敏剂Ce6偶联，开发了磁性声动力纳米机器人（FeO@SiO-Ce6，FSC）。磁性FSC纳米机器人聚集体可以在固定点聚集，并在磁场的调节下主动移动到目标部位。实验表明，磁性FSC纳米机器人聚集体能够在引导下定向导航到肿瘤细胞区域。此外，在低强度超声刺激下，FSC纳米机器人聚集体介导的声动力疗法表现出显著的抗肿瘤性能。这些发现表明，磁驱动声动力纳米机器人聚集体在靶向癌症治疗中具有广阔的应用潜力。
