Leipner N, Harder T, Hövelmann B, Schüller H, Hartlapp J H, Boldt I
Radiologische Klinik, Universität Bonn.
Strahlenther Onkol. 1987 Oct;163(10):637-42.
During the period from 1980 through 1984, 67 patients suffering from small-cell bronchial carcinomas were submitted to a complete ACO II treatment scheme combined with adjuvant irradiation. The complete remission rate was 12%, the partial remission rate 74%. Half of the patients with limited disease survived 12.3 months or more. The median survival time of patients with extensive disease was eight months. An irradiation of the tumor core had been found useful in cases where remote hematogenous metastases could not be demonstrated. It was shown that a prophylactic skull irradiation after the second chemotherapy series was applied too early, because persisting primary tumor residues formed late intracerebral metastases.
在1980年至1984年期间，67例小细胞支气管癌患者接受了完整的ACO II治疗方案并联合辅助放疗。完全缓解率为12%，部分缓解率为74%。一半局限性疾病患者存活了12.3个月或更长时间。广泛性疾病患者的中位生存时间为8个月。已发现对未证实有远处血行转移的病例进行肿瘤核心照射是有用的。结果表明，在第二个化疗疗程后过早进行预防性颅脑照射是因为持续存在的原发性肿瘤残余物形成了晚期脑内转移。
