Sun Zhong Yi, Houenou Josselin, Duclap Delphine, Sarrazin Samuel, Linke Julia, Daban Claire, Hamdani Nora, d'Albis Marc-Antoine, Le Corvoisier Philippe, Guevara Pamela, Delavest Marine, Bellivier Frank, Bellivier Frank, Almeida Jorge, Versace Amelia, Poupon Cyril, Leboyer Marion, Phillips Mary, Wessa Michèle, Mangin Jean-François
From the UNATI, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France (Sun, Mangin); the UNIACT, Psychiatry Team, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France (Houenou, Sarrazin); INSERM, U955, IMRB, Equipe 15 Psychiatrie Translationnelle, Créteil F-94000, France (Houenou, Sarrazin, Hamdani, d'Albis, Leboyer); the Fondation Fondamental, Créteil F-94010, France (Houenou, Sarrazin, Hamdani, d'Albis, Delavest, Bellivier, Leboyer); the AP-HP, Hôpitaux Universitaires Mondor, Pôle de Psychiatrie, DHU PePsy, Université Paris Est, Créteil F-94000, France (Sarrazin, Daban, Hamdani, d'Albis, Leboyer); the UNIRS, Neurospin, I2BM, CEA Saclay, Gif-Sur-Yvette, France (Duclap, Poupon); the Department of Clinical Psychology and Neuropsychology, Johannes Gutenberg University, Mainz, Germany (Linke, Wessa); INSERM, Centre d'Investigation Clinique 1430 and APHP, GH Henri Mondor, Créteil F-94000, France (Le Corvoisier); the University of Concepción, Concepción, Chile (Guevara); the AP-HP, Groupe Saint-Louis, Lariboisière-Fernand Widal, Pôle Neurosciences, Paris, France (Delavest, Bellivier); the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medecine, Pittsburgh, PA, USA (Almeida, Versace, Phillips); the Faculté de médecine, Universite Paris Est, Créteil, France (Leboyer); and the CATI Multicenter Neuroimaging Platform, France (Sun, Poupon, Mangin).
J Psychiatry Neurosci. 2017 Jan;42(1):27-36. doi: 10.1503/jpn.150291.
Abnormal maturation of brain connectivity is supposed to underlie the dysfunctional emotion regulation in patients with bipolar disorder (BD). To test this hypothesis, white matter integrity is usually investigated using measures of water diffusivity provided by MRI. Here we consider a more intuitive aspect of the morphometry of the white matter tracts: the shape of the fibre bundles, which is associated with neurodevelopment. We analyzed the shape of 3 tracts involved in BD: the cingulum (CG), uncinate fasciculus (UF) and arcuate fasciculus (AF).
We analyzed diffusion MRI data in patients with BD and healthy controls. The fibre bundles were reconstructed using Q-ball-based tractography and automated segmentation. Using Isomap, a manifold learning method, the differences in the shape of the reconstructed bundles were visualized and quantified.
We included 112 patients and 82 controls in our analysis. We found the left AF of patients to be further extended toward the temporal pole, forming a tighter hook than in controls. We found no significant difference in terms of shape for the left UF, the left CG or the 3 right fasciculi. However, in patients compared with controls, the ventrolateral branch of the left UF in the orbitofrontal region had a tendency to be larger, and the left CG of patients had a tendency to be smaller in the frontal lobe and larger in the parietal lobe.
This was a cross-sectional study.
Our results suggest neurodevelopmental abnormalities in the left AF in patients with BD. The statistical tendencies observed for the left UF and left CG deserve further study.
大脑连接性的异常成熟被认为是双相情感障碍（BD）患者情绪调节功能失调的基础。为了验证这一假设，通常使用MRI提供的水扩散率测量方法来研究白质完整性。在这里，我们考虑白质束形态学中一个更直观的方面：纤维束的形状，它与神经发育有关。我们分析了与双相情感障碍相关的3条束的形状：扣带束（CG）、钩束（UF）和弓状束（AF）。
我们分析了双相情感障碍患者和健康对照者的扩散MRI数据。使用基于Q球的纤维束成像和自动分割技术重建纤维束。使用一种流形学习方法等距映射（Isomap），对重建束的形状差异进行可视化和量化。
我们的分析纳入了112例患者和82例对照者。我们发现患者的左侧弓状束向颞极进一步延伸，形成了比对照者更紧密的钩状。我们发现左侧钩束、左侧扣带束或右侧的3条束在形状上没有显著差异。然而，与对照者相比，患者左侧钩束在眶额区域的腹外侧分支有变大的趋势，患者左侧扣带束在额叶有变小的趋势，而在顶叶有变大的趋势。
这是一项横断面研究。
我们的结果表明双相情感障碍患者左侧弓状束存在神经发育异常。左侧钩束和左侧扣带束观察到的统计学趋势值得进一步研究。
