Wilcox J, Wilson A J, Evill C A, Sage M R
Department of Radiology, Flinders Medical Centre, Bedford Park, South Australia.
AJNR Am J Neuroradiol. 1987 Sep-Oct;8(5):769-72.
A rabbit model was used to compare the effect on the blood-brain barrier of the intracarotid injection of two new contrast media: iohexol, a nonionic monomer, and iodixanol, a nonionic dimer. It was hypothesized that the low osmolality of iodixanol (272 mOsm/kg at 300 mgl/ml) would cause less disruption of the blood-brain barrier than the relatively higher osmolality of iohexol (690 mOsm/kg at 300 mgl/ml). The degree of blood-brain barrier disruption was assessed qualitatively, by observing the degree of cortical staining with Evans' Blue dye, and quantitatively, by calculating the difference in uptake of 99mTc-pertechnetate between injected and noninjected hemispheres. Statistical analysis of the results showed that both iodixanol and iohexol had a significantly greater effect on blood-brain barrier disruption than did isotonic saline (0.005 greater than p greater than .001), but that the effect of iodixanol was not significantly different from that of iohexol with respect to either Evans' Blue staining (p greater than .05) or pertechnetate uptake (.75 less than p less than .90). Thus, the low-osmolality iodixanol has no significant advantage over iohexol in terms of blood-brain barrier disruption after experimental carotid angiography.
非离子单体碘海醇和非离子二聚体碘克沙醇。研究假设碘克沙醇的低渗透压（300mg/ml时为272mOsm/kg）比碘海醇相对较高的渗透压（300mg/ml时为690mOsm/kg）对血脑屏障的破坏更小。通过观察伊文思蓝染料对皮质的染色程度进行血脑屏障破坏程度的定性评估，并通过计算注射半球和未注射半球之间高锝[99mTc]酸盐摄取的差异进行定量评估。结果的统计分析表明，碘克沙醇和碘海醇对血脑屏障破坏的影响均显著大于等渗盐水（0.005＞p＞0.001），但就伊文思蓝染色（p＞0.05）或高锝酸盐摄取而言（0.75＜p＜0.90），碘克沙醇与碘海醇的影响无显著差异。因此，在实验性颈动脉血管造影术后，就血脑屏障破坏而言，低渗透压的碘克沙醇相对于碘海醇没有显著优势。
