Wilcox J, Evill C A, Sage M R
Neuroradiology. 1986;28(3):271-4. doi: 10.1007/BF00548204.
A rabbit model was used to assess the effects of intracarotid injections of ionic monomer (meglumine iothalamate), non-ionic monomer (iohexol, iopromide), and non-ionic dimer (iotrol) contrast materials on the blood-brain barrier. The degree of blood-brain barrier damage was assessed qualitatively using Evans' blue dye, and quantitatively by calculating the difference in pertechnetate uptake between injected and non-injected hemispheres. The results showed that the non-ionic dimer, iotrol, had the least effect on the blood-brain barrier, and that although iopromide and iohexol produced greater damage than iotrol, the ionic compound, meglumine iothalamate, caused the greatest disruption to the blood-brain barrier. The implications of these findings are discussed.
采用兔模型评估经颈内动脉注射离子单体（碘他拉葡胺）、非离子单体（碘海醇、碘普罗胺）和非离子二聚体（碘曲仑）造影剂对血脑屏障的影响。使用伊文思蓝染料定性评估血脑屏障损伤程度，并通过计算注射侧与未注射侧半球高锝酸盐摄取差异进行定量评估。结果表明，非离子二聚体碘曲仑对血脑屏障的影响最小，虽然碘普罗胺和碘海醇造成的损伤比碘曲仑更大，但离子化合物碘他拉葡胺对血脑屏障的破坏最大。讨论了这些发现的意义。
