Kalucka Joanna, Bierhansl Laura, Wielockx Ben, Carmeliet Peter, Eelen Guy
Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Centre, VIB, Campus Gasthuisberg O&N4, Herestraat 49-912, Leuven, 3000, Belgium.
Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Campus Gasthuisberg O&N4, Leuven, 3000, Belgium.
Pflugers Arch. 2017 Apr;469(3-4):473-483. doi: 10.1007/s00424-017-1946-6. Epub 2017 Feb 24.
Angiogenesis and inflammation go hand in hand in various (patho-)physiological conditions. Several studies have highlighted the interconnection between endothelial cells (ECs) and macrophages in these conditions at the level of growth factor and cytokine signaling, yet the importance of metabolism and metabolic signaling has been largely overlooked. Modulating macrophage and/or endothelial functions by interfering with metabolic pathways offers new perspectives for therapeutic strategies. In this review, we highlight the complexity of the interrelationship between the inflammatory response and angiogenesis. More in particular, the interaction between macrophages and ECs will be discussed with a special focus on how their metabolism can contribute to (patho-)physiological conditions.
在各种（病理）生理条件下，血管生成与炎症密切相关。多项研究强调了在这些条件下，内皮细胞（ECs）与巨噬细胞在生长因子和细胞因子信号传导水平上的相互联系，然而，代谢和代谢信号传导的重要性在很大程度上被忽视了。通过干扰代谢途径来调节巨噬细胞和/或内皮功能为治疗策略提供了新的视角。在本综述中，我们强调了炎症反应与血管生成之间相互关系的复杂性。更具体地说，将讨论巨噬细胞与内皮细胞之间的相互作用，特别关注它们的代谢如何促成（病理）生理状况。
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