Laboratory of Angiogenesis and Redox Metabolism, Department of Molecular Biotechnology and Health Sciences, Via Nizza 52, 10126, Turin, Italy.
Semin Cell Dev Biol. 2018 Aug;80:35-42. doi: 10.1016/j.semcdb.2017.08.002. Epub 2017 Aug 8.
Formation and maturation of a functional vascular network is a process called angiogenesis. This is a crucial biological event in all vertebrates. Precise morphogenetic and cellular mechanisms act in endothelial cells (ECs) to drive angiogenesis during growth and throughout adulthood. Reactive oxygen species (ROS) and their metabolism are proving to be crucial participants in the shaping and stabilizing of blood vessels. Often, the same mechanisms are responsible for the insurgence of vascular-associated pathologies. In this review we discuss how ROS-mediated signalling events and distinctive metabolic pathways drive the biology of endothelial cells. We support the use of alternative anti-angiogenic therapy based on the manipulation of ROS signalling and metabolism to solve angiogenesis-related diseases.
血管的形成和成熟是一个被称为血管生成的过程。这是所有脊椎动物中至关重要的生物学事件。在生长和整个成年期，精确的形态发生和细胞机制作用于内皮细胞（EC）以驱动血管生成。活性氧（ROS）及其代谢被证明是血管形成和稳定的关键参与者。通常，相同的机制负责血管相关病理的发生。在这篇综述中，我们讨论了 ROS 介导的信号事件和独特的代谢途径如何驱动内皮细胞的生物学。我们支持使用基于 ROS 信号和代谢操纵的替代抗血管生成疗法来解决与血管生成相关的疾病。
