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中国肾结石的患病率:一项基于超声检查的横断面研究。

Prevalence of kidney stones in China: an ultrasonography based cross-sectional study.

作者信息

Zeng Guohua, Mai Zanlin, Xia Shujie, Wang Zhiping, Zhang Keqin, Wang Li, Long Yongfu, Ma Jinxiang, Li Yi, Wan Show P, Wu Wenqi, Liu Yongda, Cui Zelin, Zhao Zhijian, Qin Jing, Zeng Tao, Liu Yang, Duan Xiaolu, Mai Xin, Yang Zhou, Kong Zhenzhen, Zhang Tao, Cai Chao, Shao Yi, Yue Zhongjin, Li Shujing, Ding Jiandong, Tang Shan, Ye Zhangqun

机构信息

Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.

Guangdong Key Laboratory of Urology, Guangzhou Medical University, Guangzhou, Guangdong, China.

出版信息

BJU Int. 2017 Jul;120(1):109-116. doi: 10.1111/bju.13828. Epub 2017 Mar 21.

Abstract

OBJECTIVES

To investigate the prevalence and associated factors of kidney stones among adults in China.

SUBJECTS AND METHODS

A nationwide cross-sectional survey was conducted among individuals aged ≥18 years across China, from May 2013 to July 2014. Participants underwent urinary tract ultrasonographic examinations, completed pre-designed and standardised questionnaires, and provided blood and urine samples for analysis. Kidney stones were defined as particles of ≥4 mm. Prevalence was defined as the proportion of participants with kidney stones and binary logistic regression was used to estimate the associated factors.

RESULTS

A total of 12 570 individuals (45.2% men) with a mean (sd, range) age of 48.8 (15.3, 18-96) years were selected and invited to participate in the study. In all, 9310 (40.7% men) participants completed the investigation, with a response rate of 74.1%. The prevalence of kidney stones was 6.4% [95% confidence interval (CI) 5.9, 6.9], and the age- and sex-adjusted prevalence was 5.8% (95% CI 5.3, 6.3; 6.5% in men and 5.1% in women). Binary logistic regression analysis showed that male gender, rural residency, age, family history of urinary stones, concurrent diabetes mellitus and hyperuricaemia, increased consumption of meat, and excessive sweating were all statistically significantly associated with a greater risk of kidney stones. By contrast, consumption of more tea, legumes, and fermented vinegar was statistically significantly associated with a lesser risk of kidney stone formation.

CONCLUSION

Kidney stones are common among Chinese adults, with about one in 17 adults affected currently. Some Chinese dietary habits may lower the risk of kidney stone formation.

摘要

目的

调查中国成年人肾结石的患病率及相关因素。

对象与方法

2013年5月至2014年7月,在中国对年龄≥18岁的个体进行了一项全国性横断面调查。参与者接受了泌尿系统超声检查,完成了预先设计的标准化问卷,并提供了血液和尿液样本用于分析。肾结石定义为直径≥4毫米的颗粒。患病率定义为患有肾结石的参与者比例,并采用二元逻辑回归分析来估计相关因素。

结果

共选取12570名个体(男性占45.2%),平均(标准差,范围)年龄为48.8(15.3,18 - 96)岁,并邀请他们参与研究。共有9310名(男性占40.7%)参与者完成了调查,应答率为74.1%。肾结石的患病率为6.4% [95%置信区间(CI)5.9,6.9],年龄和性别调整后的患病率为5.8%(95% CI 5.3,6.3;男性为6.5%,女性为5.1%)。二元逻辑回归分析显示,男性、农村居民、年龄、尿路结石家族史、并发糖尿病和高尿酸血症、肉类摄入量增加以及多汗均与肾结石风险增加在统计学上显著相关。相比之下,饮用更多茶、食用豆类和发酵醋与肾结石形成风险降低在统计学上显著相关。

结论

肾结石在中国成年人中很常见,目前约每17名成年人中就有1人受影响。一些中国饮食习惯可能会降低肾结石形成的风险。

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