Huang Bo, Li Xin, Zhang Xin-Xin, Li Shi-Wei, Wang Meng, Chen Qing, Cao Yi-Dan, Cui Jing-Qiu
Department of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Department of Nephrology, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.
Diabetes Metab Syndr Obes. 2025 Aug 22;18:3015-3025. doi: 10.2147/DMSO.S535669. eCollection 2025.
The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) reflects systemic inflammation, combining the pro-inflammatory role of monocytes with the anti-atherogenic and anti-inflammatory properties of HDL-cholesterol. Prior studies have established MHR as an independent predictor of hyperuricemia (HUA) prevalence. Emerging evidence further identifies MHR as a potential biomarker for early type 2 diabetes mellitus (T2DM) screening, likely mediated through its association with insulin resistance. Therefore, our study specifically investigates the relationship between MHR and HUA in a T2DM population.
This cross-sectional study enrolled 1,261 T2DM patients. Logistic regression assessed associations between MHR and HUA. Mediation analysis evaluated body mass index (BMI) as a mediator. Restricted cubic spline (RCS) analysis examined nonlinear relationships. Receiver operating characteristic (ROC) curves compared predictive performance.
Elevated MHR (adjusted OR = 2.040, 95% CI: 1.023 to 4.071, p < 0.05) was independently associated with HUA risk. BMI mediated 18.59% of the associations for MHR, respectively. RCS analysis revealed nonlinear patterns, with HUA risk increasing notably when MHR > 0.47. In ROC analysis, MHR demonstrated significant predictive ability for HUA, with an area under the curve (AUC) of 0.62.
Higher MHR was significantly associated with HUA risk in T2DM patients, with BMI serving as a key mediator. These markers may aid in early identification of patients at risk and underscore the importance of weight and inflammation control in HUA prevention.
单核细胞与高密度脂蛋白胆固醇比值（MHR）反映全身炎症，它将单核细胞的促炎作用与高密度脂蛋白胆固醇的抗动脉粥样硬化和抗炎特性相结合。先前的研究已将MHR确立为高尿酸血症（HUA）患病率的独立预测指标。新出现的证据进一步确定MHR是早期2型糖尿病（T2DM）筛查的潜在生物标志物，这可能是通过其与胰岛素抵抗的关联介导的。因此，我们的研究专门调查了T2DM人群中MHR与HUA之间的关系。
这项横断面研究纳入了1261例T2DM患者。逻辑回归评估了MHR与HUA之间的关联。中介分析评估体重指数（BMI）作为中介变量。受限立方样条（RCS）分析检查非线性关系。受试者工作特征（ROC）曲线比较预测性能。
MHR升高（调整后的OR = 2.040，95%CI：1.023至4.071，p < 0.05）与HUA风险独立相关。BMI分别介导了MHR关联的18.59%。RCS分析揭示了非线性模式，当MHR > 0.47时，HUA风险显著增加。在ROC分析中，MHR对HUA具有显著的预测能力，曲线下面积（AUC）为0.62。
在T2DM患者中，较高的MHR与HUA风险显著相关，BMI是关键中介变量。这些标志物可能有助于早期识别有风险的患者，并强调体重和炎症控制在预防HUA中的重要性。
