血糖指数、血糖负荷与 ADIPOQ T45G（rs2241766）基因变异在结直肠癌风险中的相互作用：一项在韩国人群中的病例对照研究。

The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case-control study in a Korean population.

机构信息

Department of Cancer Control and Population Health, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, South Korea.

Department of Cancer Biomedical Science, National Cancer Center Graduate School of Cancer Science and Policy, Goyang-si, Gyeonggi-do, South Korea.

出版信息

Eur J Nutr. 2022 Aug;61(5):2601-2614. doi: 10.1007/s00394-022-02845-8. Epub 2022 Mar 3.

DOI:10.1007/s00394-022-02845-8

PMID:35243553

Abstract

PURPOSE

The glycemic index (GI), glycemic load (GL), and adiponectin level contribute to glycemic response and insulin sensitivity in the body. Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association of GI and GL with colorectal cancer (CRC) risk in a Korean population and their possible interactions with the genetic variant ADIPOQ T45G.

METHODS AND RESULTS

A case-control study including 2096 participants with 695 CRC cases was conducted. The results showed that diets with high GI or GL were significantly associated with an increased risk of CRC [odds ratio (OR) = 5.44, 95% confidence interval (CI) 3.85-7.68; OR = 4.43, 95% CI 3.18-6.15, respectively; all p-trends < 0.001]. Moreover, even with a low-GI and low-GL diet, G/G genotype carriers may have 2.93-fold and 3.77-fold higher risk of rectal cancer compared to carriers of other genotypes (T/T + T/G), (OR = 2.93, 95% CI 1.01-8.59, p-interaction = 0.011 for GI; OR = 3.77, 95% CI 1.46-9.77, p-interaction = 0.025 for GL).

CONCLUSIONS

Overall, our study suggests positive associations of GI and GL with CRC risk. Moreover, the associations of GI and GL with rectal cancer risk could be modified by ADIPOQ T45G in a Korean population. Further studies with larger sample sizes are needed to confirm our findings.

摘要

目的

血糖指数（GI）、血糖负荷（GL）和脂联素水平与机体的血糖应答和胰岛素敏感性有关。研究表明，肿瘤的发生与血糖紊乱有关；然而，结果却是相互矛盾的。我们旨在研究 GI 和 GL 与韩国人群结直肠癌（CRC）风险的相关性，以及它们与 ADIPOQ T45G 遗传变异的可能相互作用。

方法和结果

进行了一项包括 2096 名参与者（695 例 CRC 病例）的病例对照研究。结果表明，高 GI 或 GL 的饮食与 CRC 风险增加显著相关[比值比（OR）=5.44，95%置信区间（CI）3.85-7.68；OR=4.43，95%CI 3.18-6.15，均 P 趋势<0.001]。此外，即使采用低 GI 和低 GL 的饮食，G/G 基因型携带者发生直肠癌的风险也可能比其他基因型（T/T+T/G）携带者高 2.93 倍和 3.77 倍（OR=2.93，95%CI 1.01-8.59，p 交互=0.011；OR=3.77，95%CI 1.46-9.77，p 交互=0.025）。