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复发性脊髓海绵状血管畸形出血继发上行性脊髓梗死

Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage.

作者信息

Huntley Geoffrey D, Ruff Michael W, Hicks Stephen B, Yost Micah D, Fulgham Jimmy R

机构信息

School of Medicine, Mayo Clinic, Rochester, Minnesota.

Department of Neurology, Mayo Clinic, Rochester, Minnesota.

出版信息

J Stroke Cerebrovasc Dis. 2017 Apr;26(4):e72-e73. doi: 10.1016/j.jstrokecerebrovasdis.2017.02.013. Epub 2017 Feb 22.


DOI:10.1016/j.jstrokecerebrovasdis.2017.02.013
PMID:28236596
Abstract

We report a case of a 58-year-old Hispanic man who developed ascending paraparesis over several weeks secondary to recurrent hemorrhages and resulting in spinal cord ischemia from a low thoracic spinal cord cavernous malformation. The patient's deterioration was attributed to recurrent hemorrhage of a thoracic intramedullary cavernous malformation at T11 resulting in vascular congestion and spinal cord ischemia. The patient was found to have a heterozygous mutation on exon 13 of gene KRIT1, which was consistent with autosomal dominant familial cerebral cavernous malformations. Expedited surgical intervention potentially could have prevented this patient's progressive paraplegia.

摘要

我们报告了一例58岁的西班牙裔男性病例,该患者在数周内出现进行性双下肢轻瘫,继发于反复出血,因胸段低位脊髓海绵状血管畸形导致脊髓缺血。患者的病情恶化归因于T11节段胸段髓内海绵状血管畸形反复出血,导致血管充血和脊髓缺血。该患者在基因KRIT1的第13外显子上发现杂合突变,这与常染色体显性遗传性家族性脑海绵状血管畸形相符。尽早进行手术干预可能会预防该患者的进行性截瘫。

相似文献

[1]
Ascending Spinal Cord Infarction Secondary to Recurrent Spinal Cord Cavernous Malformation Hemorrhage.

J Stroke Cerebrovasc Dis. 2017-4

[2]
Spinal root arteriovenous malformations and same-segment cord cavernous malformation in familial cerebral cavernous malformation. Case report.

J Neurosurg Spine. 2008-9

[3]
Multiple cerebral and spinal cord cavernomas in Klippel-Trenaunay-Weber syndrome.

J Clin Neurosci. 2010-5-20

[4]
A novel KRIT1 gene mutation in a patient with cerebral and multiple spinal cavernous malformations.

Ann Clin Lab Sci. 2010

[5]
Lateral Myelotomy for Resection of a Ruptured Intramedullary Cervico-Thoracic Cavernous Malformation.

Oper Neurosurg (Hagerstown). 2021-3-15

[6]
[Intramedullary spinal cord cavernous malformations--clinical presentation and optimal management].

Przegl Lek. 2015

[7]
Microsurgical resection of intramedullary spinal cord cavernous malformation. Operative video and technical nuances.

Neurosurg Focus. 2014-9

[8]
Intramedullary cavernoma presenting with hematomyelia: report of two girls.

Childs Nerv Syst. 2010-3

[9]
Epidemiology of cavernous malformations.

Handb Clin Neurol. 2017

[10]
Multiple spinal intramedullary cavernous angiomas with bleeding episode mimicking an intramedullary tumor.

J Radiol Case Rep. 2022-3

引用本文的文献

[1]
Spinal Cord Infarcts: Risk Factors, Management, and Prognosis.

Curr Treat Options Neurol. 2017-8

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