在正常人胸神经节神经元中检测水痘-带状疱疹病毒核酸。
Detection of varicella-zoster virus nucleic acid in neurons of normal human thoracic ganglia.
作者信息
Gilden D H, Rozenman Y, Murray R, Devlin M, Vafai A
机构信息
Department of Neurology, University of Colorado School of Medicine, Denver 80262.
出版信息
Ann Neurol. 1987 Sep;22(3):377-80. doi: 10.1002/ana.410220315.
Tissue sections from four normal human thoracic ganglia were hybridized in situ with a varicella-zoster virus-RNA probe. Varicella-zoster virus was detected in two of four ganglia, localized exclusively in neurons. The detection of latent varicella-zoster virus genetic material in thoracic ganglia provides further evidence of varicella-zoster virus latency at multiple levels of the human neuraxis and supports the notion that the neuron is the primary site of herpesvirus latency.
取自四名正常人类胸神经节的组织切片与水痘-带状疱疹病毒RNA探针进行原位杂交。在四个神经节中的两个检测到水痘-带状疱疹病毒，且仅定位于神经元中。在胸神经节中检测到潜伏性水痘-带状疱疹病毒遗传物质，为水痘-带状疱疹病毒在人类神经轴多个水平的潜伏提供了进一步证据，并支持神经元是疱疹病毒潜伏的主要部位这一观点。
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