Veronesi Giulia, Colombo Paolo, Novellis Pierluigi, Crepaldi Alessandro, Lutman Romano Fabio, Dieci Elisa, Profili Manuel, Siracusano Licia, Alloisio Marco
Division of Thoracic Surgery, Humanitas Cancer Center, Rozzano, MI, Italy.
Research Unit, Doxa, Via Panizza 7, 20144 Milano, Italy.
Lung Cancer. 2017 Mar;105:39-41. doi: 10.1016/j.lungcan.2017.01.001. Epub 2017 Jan 3.
Widespread lung cancer screening with low-dose computed tomography is urgently needed in Europe to identify lung cancers early and reduce lung cancer deaths. The most effective method of identifying high-risk individuals and recruiting them for screening has not been determined. In the present pilot study we investigated direct telephoning to families as a way of identifying high risk individuals and recruiting them to a screening/smoking cessation program, that avoided the selection bias of voluntary screening. Families in the province of Milan, Italy, were contacted by telephone at their homes and asked about family members over 50 years who were heavy smokers (30 or more pack-years). Persons meeting these criteria were contacted and asked to participate in the program. Those who agreed were given an appointment to undergo screening and receive smoking cessation counseling. Among the 1000 contacted families, involving 2300 persons, 44 (1.9%) were eligible for LDCT screening, and 12 (27%) of these participated in the program. The cost of this recruitment strategy pilot study was around 150 euro per screened subject. We obtained useful information on the proportion of the general population eligible for lung cancer screening and the proportion of those who responded. However the cost of home telephone calling is probably too high to be practicable as a method of recruiting high risk persons for screening. Alternative recruitment methods, possibly involving family physicians practitioners, need to be investigated.
欧洲迫切需要开展低剂量计算机断层扫描进行广泛的肺癌筛查，以便早期发现肺癌并降低肺癌死亡率。目前尚未确定识别高危个体并招募他们进行筛查的最有效方法。在本试点研究中，我们调查了直接给家庭打电话这种方式，以识别高危个体并招募他们参加一个筛查/戒烟项目，该项目避免了自愿筛查的选择偏倚。我们通过电话联系了意大利米兰省的家庭，询问家中50岁以上的重度吸烟者（吸烟量达到30包年或以上）情况。符合这些标准的人会被联系并邀请参加该项目。同意参加的人会得到一个进行筛查和接受戒烟咨询的预约。在1000个被联系的家庭（涉及2300人）中，有44人（1.9%）符合低剂量计算机断层扫描筛查条件，其中12人（27%）参加了该项目。这项招募策略试点研究的成本约为每位接受筛查的对象150欧元。我们获得了关于符合肺癌筛查条件的普通人群比例以及有回应者比例的有用信息。然而，通过家庭电话联系的成本可能过高，作为一种招募高危人群进行筛查的方法不太可行。需要研究其他招募方法，可能包括家庭医生从业者参与的方法。
