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源自南极磷虾的二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)的电子构型结构及其对人癌细胞系体外生长的显著抑制作用。

E-configuration structures of EPA and DHA derived from Euphausia superba and their significant inhibitive effects on growth of human cancer cell lines in vitro.

作者信息

Zheng Weilong, Wang Xudong, Cao Wenjing, Yang Bowen, Mu Ying, Dong Yuesheng, Xiu Zhilong

机构信息

School of Life Science and Biotechnology, Dalian University of Technology, 2 Linggong Road, Dalian 116024, PR China.

School of Life Science and Biotechnology, Dalian University of Technology, 2 Linggong Road, Dalian 116024, PR China.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2017 Feb;117:47-53. doi: 10.1016/j.plefa.2017.01.005. Epub 2017 Jan 25.

Abstract

Many bioactive components such as poly-unsaturated fatty acids (e.g. EPA and DHA), phospholipids and astaxanthin are known in Antarctic krill (Euphausia superba) oil. The krill DHA and EPA are generally considered to be similar to natural ones. However, two chemical compounds which were separated from Antarctic krill oil and identified as EPA and DHA by HRESIMS and NMR acted much more effective inhibitive activities on growth of several cell lines (U937, K562, SMMC-7721, PC-3, MDA-MB-231, HL60 and MCF-7) than those from sturgeon liver and commercial fish oil. Taking MCF-7 as an example, the IC values of Antarctic krill EPA and DHA were 14.01 and 19.94μM,while the IC values of sturgeon liver and commercial fish EPA and DHA were 81.45, 73.13, 82.11 and 75.31μM, respectively. Raman spectra revealed that the Antarctic krill EPA and DHA have E-configuration structures, which were different from those in commercial fish oil. Additionally, the Antarctic krill EPA and DHA had no effects on human normal liver cell line HL7702. These results indicated that the Antarctic krill E-EPA and E-DHA had a great prospect in cancer therapy.

摘要

南极磷虾(Euphausia superba)油中含有许多生物活性成分,如多不饱和脂肪酸(如EPA和DHA)、磷脂和虾青素。磷虾中的DHA和EPA通常被认为与天然的相似。然而,从南极磷虾油中分离出并通过高分辨电喷雾电离质谱(HRESIMS)和核磁共振(NMR)鉴定为EPA和DHA的两种化合物,对几种细胞系(U937、K562、SMMC - 7721、PC - 3、MDA - MB - 231、HL60和MCF - 7)生长的抑制活性比鲟鱼肝脏和市售鱼油中的同类化合物更强。以MCF - 7为例,南极磷虾EPA和DHA的半数抑制浓度(IC)值分别为14.01和19.94μM,而鲟鱼肝脏和市售鱼油中EPA和DHA的IC值分别为81.45、73.13、82.11和75.31μM。拉曼光谱显示,南极磷虾EPA和DHA具有E - 构型结构,这与市售鱼油中的不同。此外,南极磷虾EPA和DHA对人正常肝细胞系HL7702没有影响。这些结果表明,南极磷虾E - EPA和E - DHA在癌症治疗方面具有广阔前景。

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