Ulven Stine M, Kirkhus Bente, Lamglait Amandine, Basu Samar, Elind Elisabeth, Haider Trond, Berge Kjetil, Vik Hogne, Pedersen Jan I
Faculty of Health, Nutrition, and Management, Akershus University College, Lillestrøm, Norway.
Lipids. 2011 Jan;46(1):37-46. doi: 10.1007/s11745-010-3490-4. Epub 2010 Nov 2.
The purpose of the present study is to investigate the effects of krill oil and fish oil on serum lipids and markers of oxidative stress and inflammation and to evaluate if different molecular forms, triacylglycerol and phospholipids, of omega-3 polyunsaturated fatty acids (PUFAs) influence the plasma level of EPA and DHA differently. One hundred thirteen subjects with normal or slightly elevated total blood cholesterol and/or triglyceride levels were randomized into three groups and given either six capsules of krill oil (N = 36; 3.0 g/day, EPA + DHA = 543 mg) or three capsules of fish oil (N = 40; 1.8 g/day, EPA + DHA = 864 mg) daily for 7 weeks. A third group did not receive any supplementation and served as controls (N = 37). A significant increase in plasma EPA, DHA, and DPA was observed in the subjects supplemented with n-3 PUFAs as compared with the controls, but there were no significant differences in the changes in any of the n-3 PUFAs between the fish oil and the krill oil groups. No statistically significant differences in changes in any of the serum lipids or the markers of oxidative stress and inflammation between the study groups were observed. Krill oil and fish oil thus represent comparable dietary sources of n-3 PUFAs, even if the EPA + DHA dose in the krill oil was 62.8% of that in the fish oil.
本研究的目的是调查磷虾油和鱼油对血脂、氧化应激标志物和炎症标志物的影响，并评估ω-3多不饱和脂肪酸（PUFAs）的不同分子形式（三酰甘油和磷脂）是否对血浆中二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）水平有不同影响。113名总胆固醇和/或甘油三酯水平正常或略高的受试者被随机分为三组，分别每日服用6粒磷虾油胶囊（N = 36；3.0克/天，EPA + DHA = 543毫克）或3粒鱼油胶囊（N = 40；1.8克/天，EPA + DHA = 864毫克），持续7周。第三组不接受任何补充剂，作为对照组（N = 37）。与对照组相比，补充n-3 PUFAs的受试者血浆中的EPA、DHA和二十二碳五烯酸（DPA）显著增加，但鱼油组和磷虾油组之间任何一种n-3 PUFAs的变化均无显著差异。研究组之间在任何血脂、氧化应激标志物和炎症标志物的变化上均未观察到统计学上的显著差异。因此，磷虾油和鱼油是n-3 PUFAs相当的膳食来源，尽管磷虾油中EPA + DHA的剂量是鱼油中的62.8%。
