EB 病毒与系统性红斑狼疮、类风湿关节炎和多发性硬化症——关联与病因。
Epstein-Barr virus in systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis—association and causation.
机构信息
Institute of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
出版信息
Viruses. 2012 Dec;4(12):3701-30. doi: 10.3390/v4123701.
Abstract
Epidemiological data suggest that the Epstein-Barr virus (EBV) is associated with several autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis and multiple sclerosis. However, it is not clear whether EBV plays a role in the pathogenesis of these diseases, and if so, by which mechanisms the virus may contribute. In this review, we discuss possible viral and immunological mechanisms that might explain associations between EBV and autoimmune diseases and whether these associations represent causes or effects of inflammation and autoimmunity.
摘要
流行病学数据表明，爱泼斯坦-巴尔病毒（EBV）与几种自身免疫性疾病有关，如系统性红斑狼疮、类风湿关节炎和多发性硬化症。然而，目前尚不清楚 EBV 是否在这些疾病的发病机制中起作用，如果是，病毒可能通过哪些机制发挥作用。在这篇综述中，我们讨论了可能的病毒和免疫学机制，可以解释 EBV 与自身免疫性疾病之间的关联，以及这些关联是代表炎症和自身免疫的原因还是结果。
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1
Expression and activation by Epstein Barr virus of human endogenous retroviruses-W in blood cells and astrocytes: inference for multiple sclerosis.
PLoS One. 2012;7(9):e44991. doi: 10.1371/journal.pone.0044991. Epub 2012 Sep 27.
2
Graft versus host disease in the bone marrow, liver and thymus humanized mouse model.
PLoS One. 2012;7(9):e44664. doi: 10.1371/journal.pone.0044664. Epub 2012 Sep 5.
3
Toll-like receptor 7 stimulates the expression of Epstein-Barr virus latent membrane protein 1.
PLoS One. 2012;7(8):e43317. doi: 10.1371/journal.pone.0043317. Epub 2012 Aug 31.
4
Persistence of Epstein-Barr virus in self-reactive memory B cells.
J Virol. 2012 Nov;86(22):12330-40. doi: 10.1128/JVI.01699-12. Epub 2012 Sep 5.
5
Month of birth, vitamin D and risk of immune-mediated disease: a case control study.
BMC Med. 2012 Jul 6;10:69. doi: 10.1186/1741-7015-10-69.
6
The risk of developing multiple sclerosis in individuals seronegative for Epstein-Barr virus: a meta-analysis.
Mult Scler. 2013 Feb;19(2):162-6. doi: 10.1177/1352458512449682. Epub 2012 Jun 11.
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Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNFα in monocytes.
Ann Rheum Dis. 2013 Mar;72(3):418-26. doi: 10.1136/annrheumdis-2011-201203. Epub 2012 Jun 23.
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Epstein-Barr virus early antigen diffuse (EBV-EA/D)-directed immunoglobulin A antibodies in systemic lupus erythematosus patients.
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9
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10
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J Neuroimmunol. 2012 Jun 15;247(1-2):70-4. doi: 10.1016/j.jneuroim.2012.03.014. Epub 2012 Apr 11.
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