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一只年轻成年犬复发性颈动脉体瘤的非典型病例：组织病理学、免疫组织化学及电子显微镜研究

An atypical case of recurrent carotid body carcinoma in a young adult dog: Histopathological, immunohistochemical and electron microscopic study.

作者信息

Teh Angeline Ping Ping, Pratakpiriya Watanyoo, Hidaka Yuichi, Sato Hiroyuki, Hirai Takuya, Yamaguchi Ryoji

机构信息

Laboratory of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Gakuen-kibanadai-nishi-1-1, Miyazaki 889-2192, Japan.

出版信息

J Vet Med Sci. 2017 Apr 5;79(4):714-718. doi: 10.1292/jvms.16-0501. Epub 2017 Feb 27.

DOI:10.1292/jvms.16-0501
PMID:28239052
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5402192/
Abstract

A 3.5-year-old female Chihuahua was presented with complaint of neck pain, intermittent cough and dysphagia. Physical examination and diagnostic imaging of neck region revealed a solid and highly vascularized mass involving the retropharyngeal region. Histologically, the mass showed an atypical zellballen pattern which comprised of high density of type I chief cells with high nuclear cytoplasmic ratio and separated by delicate fibrovascular stroma. Immunoreactivity for neuroendocrine markers was diffusely positive in cytoplasm of tumor cells. Disseminated tumor emboli in external jugular vein were detected 6 months after initial surgery. An electron microscopic study revealed numerous electron-dense intracytoplasmic neurosecretory granules. Based on these findings, carotid body carcinoma was diagnosed.

摘要

一只3.5岁的雌性吉娃娃犬因颈部疼痛、间歇性咳嗽和吞咽困难前来就诊。颈部体格检查和诊断性影像学检查发现一个实性且血管丰富的肿块，累及咽后区域。组织学上，肿块呈现非典型的巢状结构，由高密度的I型主细胞组成，核质比高，被纤细的纤维血管间质分隔。肿瘤细胞胞质中神经内分泌标志物免疫反应呈弥漫性阳性。初次手术后6个月，在外颈静脉检测到播散性肿瘤栓子。电子显微镜研究显示大量电子致密的胞质内神经分泌颗粒。基于这些发现，诊断为颈动脉体瘤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/32f8cc2116a4/jvms-79-714-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/67929697d341/jvms-79-714-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/58a475769a32/jvms-79-714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/04f7bd7cc9a7/jvms-79-714-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/3c0e9149c99a/jvms-79-714-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/d1c074a6c9d9/jvms-79-714-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/32f8cc2116a4/jvms-79-714-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/67929697d341/jvms-79-714-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/ff57df149e56/jvms-79-714-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/58a475769a32/jvms-79-714-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/04f7bd7cc9a7/jvms-79-714-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/3c0e9149c99a/jvms-79-714-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/d1c074a6c9d9/jvms-79-714-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01cb/5402192/32f8cc2116a4/jvms-79-714-g007.jpg

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J Comp Pathol. 2013 Aug-Oct;149(2-3):182-91. doi: 10.1016/j.jcpa.2012.12.007. Epub 2013 Mar 7.
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Magnetic resonance and computed tomography imaging of a carotid body tumor in a dog.
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Cases with manifestation of chemodectoma diagnosed in dogs in Department of Internal Diseases with Horses, Dogs and Cats Clinic, Veterinary Medicine Faculty, University of Environmental and Life Sciences, Wroclaw, Poland.在波兰弗罗茨瓦夫环境与生命科学大学马、狗和猫临床兽医系内科，诊断出患有化学感受器瘤的犬病例。
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Carotid body tumor in dog: a case report.犬颈动脉体瘤：一例报告
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