Berrettini W H, Bardakjian J, Cappellari C B, Barnett A L, Albright A, Nurnberger J I, Gershon E S
Clinical Neurogenetics Branch, DIRP, NIMH, Bethesda, MD 20892.
Biol Psychiatry. 1987 Dec;22(12):1439-43. doi: 10.1016/0006-3223(87)90101-6.
Beta-adrenergic receptor function was assessed in cultured skin fibroblasts obtained from bipolar patients and normal volunteers by measurement of the cyclic adenosine monophosphate (cAMP) response to isoproterenol. No group differences were observed. To assess regulation of receptor desensitization, fibroblasts were incubated for 24 hr with isoproterenol, and then the cAMP response to isoproterenol was determined. Subsensitivity to rechallenge with isoproterenol did not distinguish bipolar patients from controls.
通过测量对异丙肾上腺素的环磷酸腺苷（cAMP）反应，评估了从双相情感障碍患者和正常志愿者获取的培养皮肤成纤维细胞中的β-肾上腺素能受体功能。未观察到组间差异。为了评估受体脱敏的调节，将成纤维细胞与异丙肾上腺素孵育24小时，然后测定对异丙肾上腺素的cAMP反应。对异丙肾上腺素再次刺激的敏感性降低并未区分双相情感障碍患者和对照组。
