Pandey G N, Dysken M W, Garver D L, Davis J M
Am J Psychiatry. 1979 May;136(5):675-8. doi: 10.1176/ajp.136.5.675.
In a study of beta-adrenergic receptor sensitivity, the authors determined the response of cyclic AMP synthesis to in vitro addition of norepinephrine (NE) and isoproterenol (IP) in leukocytes of patients with affective illness and schizophrenia and of normal controls. IP-stimulated increase in 3H-cyclic AMP synthesis in depressed patients was significantly lower than in normal subjects and schizophrenic patients. These results suggest that beta-adrenergic receptor sensitivity is reduced in depressive illness.
在一项关于β-肾上腺素能受体敏感性的研究中，作者测定了情感性疾病和精神分裂症患者以及正常对照者白细胞中环磷酸腺苷（cAMP）合成对体外添加去甲肾上腺素（NE）和异丙肾上腺素（IP）的反应。抑郁患者中IP刺激引起的3H-cAMP合成增加显著低于正常人和精神分裂症患者。这些结果表明，抑郁性疾病中β-肾上腺素能受体敏感性降低。
