[核苷与α-干扰素联合作用对单纯疱疹Ⅱ型病毒复制的抑制]

[Combined action of nucleosides and alpha-interferon in inhibiting the reproduction of the herpes simplex type-II virus].

作者信息

Temicheva E V, Malinovskaia V V, Manakhova L S, Mironova L L, Galegov G A

出版信息

Biull Eksp Biol Med. 1987 Oct;104(10):490-2.

Abstract

Therapeutic effect of four combinations of antiherpetic chemical preparations--acyclovir (ACV), 9-beta-D-arabinofuranosyladenine (ARA-A) and E-5-(2-bromovinyl)-2'-desoxyuridine (BVDU)--has been studied. Mutual enhancement was observed in all the combinations studied, except for ACV and ARA-A combination, where partial antagonism was observed. ACV + BVDU was shown to be the most optimal combination, with the minimum inhibitory concentration (MIC) of BVDU decreasing 400-fold. A significant enhancement of nucleosides antiviral effect was noted when the human leucocyte interferon was used with the combinations. Along with synergistic effect during the interaction of alpha-interferon with ACV the antagonism in the combination of alpha-interferon with ARA-A was observed.

摘要

研究了四种抗疱疹化学制剂组合——阿昔洛韦（ACV）、9-β-D-阿拉伯呋喃糖基腺嘌呤（ARA-A）和E-5-（2-溴乙烯基）-2'-脱氧尿苷（BVDU）——的治疗效果。在所研究的所有组合中均观察到相互增强作用，但ACV和ARA-A组合除外，在该组合中观察到部分拮抗作用。ACV+BVDU被证明是最优化的组合，BVDU的最低抑菌浓度（MIC）降低了400倍。当人白细胞干扰素与这些组合一起使用时，核苷的抗病毒作用显著增强。在α-干扰素与ACV相互作用期间除了协同作用外，还观察到α-干扰素与ARA-A组合中的拮抗作用。