对一名儿童引起心内膜炎的菌株进行基因组分析。
Genomic analysis of a strain causing endocarditis in a child.
作者信息
Beye M, El Karkouri K, Labas N, Raoult D, Fournier P-E
机构信息
URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France.
URMITE, UM63, CNRS7278, IRD198, Inserm1095, Institut Hospitalo-Universitaire Méditerranée-infection, Aix-Marseille Université, Faculté de Médecine, Marseille, France; Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia.
出版信息
New Microbes New Infect. 2017 Jan 28;17:1-6. doi: 10.1016/j.nmni.2017.01.007. eCollection 2017 May.
We sequenced the genome of strain G773 that caused an infective endocarditis in a 4-year-old boy suffering from acute endocarditis. The 1.9-Mb genome exhibited a specific combination of virulence factors including a complete integrative and conjugative element, sp2905, previously described as incomplete in . , and five bacteriocin-coding genes. However, strain G773 lacked a CRISPR-Cas system.
我们对菌株G773的基因组进行了测序，该菌株在一名患有急性心内膜炎的4岁男孩身上引发了感染性心内膜炎。这个190万个碱基对的基因组展现出了毒力因子的特定组合，包括一个完整的整合性接合元件sp2905，该元件在之前被描述为不完整。此外，还有五个细菌素编码基因。然而，菌株G773缺乏CRISPR-Cas系统。
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