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本文引用的文献

1
Two distinct genetic elements are responsible for erm(TR)-mediated erythromycin resistance in tetracycline-susceptible and tetracycline-resistant strains of Streptococcus pyogenes.两种不同的遗传元件负责 erm(TR)介导的四环素敏感和四环素耐药的酿脓链球菌株的红霉素耐药性。
Antimicrob Agents Chemother. 2011 May;55(5):2106-12. doi: 10.1128/AAC.01378-10. Epub 2011 Feb 22.
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Macrolide and tetracycline resistance and emm type distribution of Streptococcus pyogenes isolates recovered from Turkish patients.从土耳其患者中分离出的酿脓链球菌对大环内酯类和四环素类的耐药性及 emm 型分布情况。
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Integrative and conjugative elements: mosaic mobile genetic elements enabling dynamic lateral gene flow.整合子和转座子：镶嵌可移动遗传元件，实现动态水平基因转移。
Nat Rev Microbiol. 2010 Aug;8(8):552-63. doi: 10.1038/nrmicro2382. Epub 2010 Jul 5.
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Antibiotic resistance and its cost: is it possible to reverse resistance?抗生素耐药性及其代价：逆转耐药性是否可行？
Nat Rev Microbiol. 2010 Apr;8(4):260-71. doi: 10.1038/nrmicro2319. Epub 2010 Mar 8.
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Genetic elements responsible for erythromycin resistance in streptococci.链球菌中负责红霉素抗性的遗传元件。
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New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae.肺炎链球菌中携带红霉素抗性决定簇erm(TR)的新型遗传元件。
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Clonal spread of macrolide- and tetracycline-resistant [erm(A) tet(O)] emm77 Streptococcus pyogenes isolates in Italy and Norway.耐大环内酯类和四环素类[erm(A) tet(O)]的致病变异型77化脓性链球菌分离株在意大利和挪威的克隆传播。
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The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.多重耐药的人类病原体艰难梭菌拥有高度可移动的镶嵌基因组。
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Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis.1999年至2002年间从希腊患扁桃体咽炎儿童中分离出的化脓性链球菌菌株对红霉素和泰利霉素的耐药性：表型和基因型分析
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ICESP2905，即酿脓链球菌的 erm(TR)-tet(O) 元件，由两个独立的整合性和接合性元件组成。

ICESp2905, the erm(TR)-tet(O) element of Streptococcus pyogenes, is formed by two independent integrative and conjugative elements.

机构信息

Department of Biomedical Sciences, Section of Microbiology, Marche Polytechnic University, Ancona, Italy.

出版信息

Antimicrob Agents Chemother. 2012 Jan;56(1):591-4. doi: 10.1128/AAC.05352-11. Epub 2011 Oct 10.

DOI:10.1128/AAC.05352-11
PMID:21986826
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3256084/
Abstract

In ICESp2905, a widespread erm(TR)- and tet(O)-carrying genetic element of Streptococcus pyogenes, the two resistance determinants are contained in separate fragments inserted into a scaffold of clostridial origin. ICESp2905 (∼65.6 kb) was transferable not only in its regular form but also in a defective form lacking the erm(TR) fragment (ICESp2906, ∼53.0 kb). The erm(TR) fragment was also an independent integrative and conjugative element (ICE) (ICESp2907, ∼12.6 kb). ICESp2905 thus results from one ICE (ICESp2907) being integrated into another (ICESp2906).

摘要

在 ICESp2905 中，存在一个广泛传播的携带 erm(TR)和 tet(O)的酿脓链球菌遗传元件，这两个抗性决定簇分别包含在插入梭菌起源支架的不同片段中。ICESp2905（约 65.6 kb）不仅可以以完整形式转移，还可以以缺失 erm(TR)片段的缺陷形式（ICESp2906，约 53.0 kb）转移。erm(TR)片段也是一个独立的整合和共轭元件（ICE）（ICESp2907，约 12.6 kb）。因此，ICESp2905 是由一个 ICE（ICESp2907）整合到另一个 ICE（ICESp2906）中形成的。