Shavelle Robert, Vavra-Musser Kate, Lee Jessica, Brooks Jordan
Life Expectancy Project, San Francisco, CA, USA.
Lung Cancer Int. 2017;2017:2782590. doi: 10.1155/2017/2782590. Epub 2017 Jan 23.
. Mesothelioma is a rare cancer with a historically dire prognosis. We sought to calculate life expectancies for patients with pleural or peritoneal mesothelioma, both at time of diagnosis and several years later, and to examine whether survival has improved in recent years. . Data on 10,258 pleural and 1,229 peritoneal patients from the SEER US national cancer database, 1973-2011, were analyzed using the Cox proportional hazards regression model. . The major factors related to survival were age, sex, stage, grade, histology, and treatment. Survival improved only modestly over the study period: 0.5% per year for pleural and 2% for peritoneal. . Life expectancies were markedly reduced from normal, even amongst 5-year survivors with the most favorable characteristics and treatment options.
间皮瘤是一种罕见的癌症，其预后历来很差。我们试图计算胸膜或腹膜间皮瘤患者在诊断时以及数年后的预期寿命，并研究近年来生存率是否有所提高。对1973年至2011年美国监测、流行病学和最终结果（SEER）国家癌症数据库中10258例胸膜间皮瘤患者和1229例腹膜间皮瘤患者的数据，使用Cox比例风险回归模型进行分析。与生存相关的主要因素包括年龄、性别、分期、分级、组织学和治疗。在研究期间，生存率仅略有提高：胸膜间皮瘤患者每年提高0.5%，腹膜间皮瘤患者每年提高2%。即使是具有最有利特征和治疗选择的5年幸存者，其预期寿命也明显低于正常水平。
