神经肽Y受体参与大鼠心肌收缩力的调节。

NPY Receptors Participate in the Regulation of Myocardial Contractility in Rats.

作者信息

Masliuko P M, Anikina T A, Zverev A A, Krylova A V, Moiseev K Yu, Zefirov T L

机构信息

Department of Normal Physiology and Biophysics, Yaroslavl State Medical University, Yaroslavl, Russia.

Department of Anatomy, Physiology, and Human Health Protection, Kazan Federal University, Kazan, Russia.

出版信息

Bull Exp Biol Med. 2017 Feb;162(4):418-420. doi: 10.1007/s10517-017-3629-x. Epub 2017 Feb 27.

DOI:10.1007/s10517-017-3629-x

PMID:28239793

Abstract

Selective agonist (Leu(31)Pro(34)NPY) and blocker (BIBP-3226) of NPY1 receptors were used to determine the type of NPY receptors involved in myocardial contraction. Experiments with isometric contraction of myocardial strips from mature rats showed that the agonist produced the most potent effect in a concentration of 10 M. In this concentration, Leu(31)Pro(34)NPY showed the greatest positive inotropic effect on the contraction of the atria and ventricles. In contrast, selective blocker BIBP-3226 reduced the force of myocardial contractions. Pretreatment of myocardial strips with this blocker abolished the positive inotropic effect of Leu(31)Pro(34)NPY, which attested to important role of NPY receptors in myocardial contraction.

摘要

使用NPY1受体的选择性激动剂（Leu(31)Pro(34)NPY）和阻滞剂（BIBP - 3226）来确定参与心肌收缩的NPY受体类型。对成年大鼠心肌条进行等长收缩实验表明，该激动剂在浓度为10 M时产生最显著的效应。在此浓度下，Leu(31)Pro(34)NPY对心房和心室收缩表现出最大的正性肌力作用。相反，选择性阻滞剂BIBP - 3226降低了心肌收缩力。用该阻滞剂预处理心肌条消除了Leu(31)Pro(34)NPY的正性肌力作用，这证明了NPY受体在心肌收缩中起重要作用。