血管活性肠肽改变大鼠心肌收缩的频率和力度。
Vasoactive Intestinal Peptide Changes the Frequency and Force of Myocardial Contraction in Rats.
机构信息
Department of Human Anatomy, Physiology, and Health Protection, Kazan (Volga region) Federal University, Kazan, Republic of Tatarstan, Russia.
出版信息
Bull Exp Biol Med. 2020 Oct;169(6):787-790. doi: 10.1007/s10517-020-04979-3. Epub 2020 Oct 24.
We studied the effect of non-selective agonist of VIP receptors of vasoactive intestinal polypeptide in different concentrations on the frequency, force, and duration of isometric contraction of myocardial strips of the right atrium under conditions of spontaneous activity, as well as the force and duration of contractions of the right ventricle in rats. It was found that the agonist produced a positive inotropic and chronotropic effect that depended on its concentration. The maximum effect was observed at vasoactive intestinal peptide concentration of 10 M.
我们研究了不同浓度的血管活性肠肽（VIP）非选择性受体激动剂对自发活动状态下右心房心肌条的等长收缩频率、幅度和时程，以及大鼠右心室收缩幅度和时程的影响。结果发现，该激动剂产生的正性变力和变时作用与其浓度有关，在血管活性肠肽浓度为 10μM 时观察到最大效应。
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