Harris Jamie, Klonoski Samuel C, Chiu Bill
Department of Surgery, Rush University Medical Center, 1750 W, Harrison Street, Suite 785, Chicago, IL 60612. United States.
Department of Surgery, University of Illinois at Chicago, 840 S. Wood Street, Suite 416, Chicago, IL 60612. United States.
Curr Drug Deliv. 2017;14(5):588-596. doi: 10.2174/1567201814666170224143706.
According to the US Center for Disease Control, cancer deaths are the second most common cause of mortality in both adults and children. Definitive treatment of solid tumors involves surgical resection with or without systemic chemotherapy and radiation. The advent of local drug delivery presents a unique treatment modality that can offer substantial benefits in cancer management. Three main phases in solid tumor management exist for the treating physician: initial diagnosis with tissue biopsy, surgical resection with or without chemotherapy, and management of metastatic disease.
A literature review of both basic science as well as clinical trials using local drug delivery strategies in the management of solid tumors was done on PubMed. These were then further divided into the categories of initial tissue biopsy intervention, surgical resection, and management of metastatic disease.
A total of 27 articles were review that included both pre-clinical as well as clinical investigation of local drug delivery therapies in the treatment of solid tumors. Treatments such as MRI guided therapies, FDA approved local therapies for intracranial gliomas as well as local therapy for single site metastatic disease were identified.
This review focuses the current state of local drug delivery in the treatment of solid tumors in both the pre-clinical as well as clinical investigation settings. Local drug delivery therapy offers an exciting new treatment modality for solid malignancies.
根据美国疾病控制中心的数据，癌症死亡是成人和儿童中第二大常见死因。实体瘤的确定性治疗包括手术切除，可联合或不联合全身化疗及放疗。局部给药的出现提供了一种独特的治疗方式，在癌症治疗中可带来显著益处。对于治疗医生而言，实体瘤治疗存在三个主要阶段：通过组织活检进行初始诊断、进行有或无化疗的手术切除以及转移性疾病的管理。
在PubMed上对使用局部给药策略治疗实体瘤的基础科学及临床试验进行了文献综述。然后将这些进一步分为初始组织活检干预、手术切除和转移性疾病管理类别。
共综述了27篇文章，包括局部给药疗法治疗实体瘤的临床前及临床研究。确定了如磁共振成像引导疗法、美国食品药品监督管理局批准的颅内胶质瘤局部疗法以及单部位转移性疾病的局部疗法等治疗方法。
本综述聚焦于临床前及临床研究环境中局部给药治疗实体瘤的当前状况。局部给药疗法为实体恶性肿瘤提供了一种令人兴奋的新治疗方式。
