Minsky B D, Mies C, Rich T A, Recht A, Chaffey J T
Department of Radiation Therapy, Harvard Medical School, Boston, Massachusetts.
Cancer. 1987 Dec 15;60(12):3103-12. doi: 10.1002/1097-0142(19871215)60:12<3103::aid-cncr2820601241>3.0.co;2-6.
To determine the clinicopathologic significance of colloid carcinoma in carcinoma of the colon and rectosigmoid/rectum, a retrospective review of 462 patients who underwent potentially curative surgery at the New England Deaconess Hospital was performed. Seventy-seven patients (17%) were identified who had tumors with some component of colloid present. Colloid carcinoma occurred in 49 (11%). The remaining 28 (6%) had adenocarcinoma with colloid features. Compared to patients with pure adenocarcinoma, the 5-year actuarial survival of patients with colloid carcinoma was lower in the colon, rectosigmoid/rectum, and colorectum. Patterns of failure, expressed as the actuarial incidence of failure at 5 years, were examined by histologic condition and stage. Patients with Dukes' Stage B colloid carcinoma had a higher incidence of total failure, and patients with Dukes' Stage C colloid carcinoma had a higher incidence of local, abdominal, and total failure. None of the differences reached statistical significance. The presence of colloid carcinoma may have a real but small impact on the patterns of failure and survival in colorectal cancer.
为确定结肠和直肠乙状结肠/直肠的黏液腺癌的临床病理意义，我们对在新英格兰女执事医院接受了根治性手术的462例患者进行了回顾性研究。我们确定了77例（17%）患者，其肿瘤含有某些黏液成分。黏液腺癌有49例（11%）。其余28例（6%）为具有黏液特征的腺癌。与单纯腺癌患者相比，黏液腺癌患者在结肠、直肠乙状结肠/直肠和结直肠的5年精算生存率较低。根据组织学情况和分期检查了失败模式，以5年失败精算发生率表示。Dukes B期黏液腺癌患者的总失败发生率较高，Dukes C期黏液腺癌患者的局部、腹部和总失败发生率较高。这些差异均未达到统计学显著性。黏液腺癌的存在可能对结直肠癌的失败模式和生存率有实际但较小的影响。
