Rey J A, Bello M J, de Campos J M, Kusak M E, Ramos C, Benitez J
Department of Genetics, Fundación Jiménez Díaz, Madrid, Spain.
Cancer Genet Cytogenet. 1987 Dec;29(2):201-21. doi: 10.1016/0165-4608(87)90232-9.
Cytogenetic analysis by direct and/or in vitro preparations was performed on 34 malignant astrocytomas. Thirty tumors showed near-diploid chromosome numbers, whereas, tritetraploid chromosome complements were present in four tumors. The most frequent chromosomal changes implied numerical deviations by a gain of chromosomes #7, #19, and #20, and by losses of #10, #22, and Y. Structural rearrangements were present in stem- or side lines of 24 tumors. Although no common chromosomal rearrangement seems to exist among those tumors, chromosomes #1, #6, #7, and #9 were predominantly involved. Polysomy and structural rearrangements of chromosome #7 could be related to the overexpression of epidermal growth factor gene, previously observed in some malignant gliomas.
对34例恶性星形细胞瘤进行了直接和/或体外制备的细胞遗传学分析。30例肿瘤显示近二倍体染色体数目，而4例肿瘤存在超四倍体染色体组成。最常见的染色体变化表现为通过增加7号、19号和20号染色体以及减少10号、22号染色体和Y染色体而导致的数值偏差。24例肿瘤的主干或旁系中存在结构重排。尽管这些肿瘤之间似乎不存在常见的染色体重排，但1号、6号、7号和9号染色体主要受累。7号染色体的多体性和结构重排可能与先前在一些恶性胶质瘤中观察到的表皮生长因子基因的过表达有关。
